The Health and Safety Environmental Institute (HESI) is seeking proposals for studies to develop human-relevant, mechanism-based assays evaluating cardiac safety liabilities. Assays should focus on any of six failure modes:

  • Changes in blood pressure or heart rate
  • Changes in contractility and ejection fraction
  • Electrophysiology
  • Cardiac cell injury
  • Valvular injury or proliferation
  • Hemorrhage and coagulation

Awards of up to $50,000 will be awarded for 12-month projects. Awardees must be based in the United States. Letters of intent are due June 8. More information is available at https://hesiglobal.org/cardiac-safety-technical-committee/.