The U.S. Environmental Protection Agency (EPA) hosted the Second Annual “Conference on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing” virtually on October 19-20. The virtual conference was presented in response to the September 2019 directive by EPA Administrator Andrew Wheeler to reduce the EPA’s use of mammalian studies.

Conference topics included:

• Implementation of animal testing reduction at EPA.
• State of the science in development of NAMs.
• Current limitations of NAMs.
• Developing scientific confidence in NAMs.

To view the conference presentations and recordings, visit the conference website at If you attended the conference and would like to submit feedback on the EPA New Approach Methods Work Plan, email