Experts from ECHA and Member States have found critical issues in the design and conduct of extended one-generation reproductive toxicity (EOGRT) studies. The issues can compromise data analysis and may raise questions over compliance or requests for further studies if there is a concern. ECHA encourages registrants and test laboratories to consider the issues and improve ongoing and future EOGRT studies accordingly.

The EOGRT study (EU B.56, OECD TG 443) has been the information requirement for reproductive toxicity in REACH since March 2015. 

ECHA’s advice on improving EOGRT studies