Archiving genetically altered mouse strains reduces animal wastage and maintains genetic integrity, maximising data reproducibility. Cryopreserved resources are also often the best means of sharing genetically altered strains, providing further opportunities for reduction in animal use and minimising the need for strain duplication. Working with colony management experts, the NC3Rs has updated existing guidance to provide an overview of current best practice, highlighting the reduction and refinement opportunities from archiving and sharing.

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