New Test Guidelines available from OECD

The Organisation for Economic Cooperation and Development (OECD) published several Test Guidelines on 25 June 2024.

Three new Test Guidelines:

• Test No. 252: Rapid Estrogen Activity In Vitro (REACTIV) assay
• Test No. 253: Short-term juvenile hormone (JH) activity screening assay in Daphnia magna
• Test No. 321: Hyallela Azteca Bioconcentration Test (HYBIT)

The following Test Guidelines were updated:

• Test No. 442D: In Vitro Skin Sensitisation
• Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation
• Test No. 496: In vitro Macromolecular Test Method for Identifying Chemicals Inducing Serious Eye Damage and Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

The following Test Guidelines were corrected/clarified:

• Test No. 493: Performance-Based Test Guideline for Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals with ER Binding Affinity
• Test No. 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage
• Test No. 442C: In Chemico Skin Sensitisation
• Test No. 442B: Skin Sensitization
• Test No. 403: Acute Inhalation Toxicity
• Test No. 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification
• Test No. 442E: In Vitro Skin Sensitisation