The NC3Rs has previously described a 3Rs “valley of death” between the development of new 3Rs technologies and approaches and their subsequent uptake into practice. This lag is influenced by a range of factors including a lack of information in the published literature on 3Rs approaches such that awareness of their utility can be poor.  
The collaboration with F1000Research and its open and rapid publication model is part of the NC3Rs strategy to tackle the “valley of death” for the research it funds. This is by ensuring that the outputs of its investment in 3Rs R&D are not only widely available but that they contain sufficient technical detail to enable others in the scientific community to make an informed decision as to whether the new models and tools are appropriate for their purposes. To ensure that the scientific literature is complete, the NC3Rs will be working closely with their grant holders to identify gaps in information that could be filled by publishing in the NC3Rs portal.
The NC3Rs is the UK’s major funder of 3Rs research, committing around £8 million each year in grants and early career awards. The portal (one of F1000Research’s Gateways) will ensure that its grant holders have an opportunity to publish the full extent of their work, avoiding publication bias. The primary focus will be on providing a format where NC3Rs grant holders can describe the method development, its performance characteristics and steps taken to validate it as well as a full exposition of the 3Rs impacts. This information is relevant to a wide range of stakeholders including scientific peers and collaborators as well as ethics committees and regulators who are charged with ensuring the 3Rs are put into practice. 



The NC3Rs Gateway can be found at

NC3Rs News, May 18, 2018