,Reactome,High-level node,4:2 FTOH,8:2 FTOH,PFBS,PFDS-Na,8:2 FTS,6:2 FTS,PFPOH,DDFHp,PFOAM,PFNAM,PFOAMD,3:3 FTCA ,PFOA,PFTeDA,PFTiDA,NH4PFOA,PFDA,PFUnDA,PFNA,TFPrOA,PFHpA,PFHx2Et2OA,PFMPA,PFPE-6,PFMOBA 1,Translation,Translation,6.420305115,4.807807579,3.915483448,6.978265822,6.057487432,1.721056069,4.81735188,1.034110636,6.35123286,NA,1.456722783,NA,2.952962191,2.826387365,1.123063902,1.326379657,5.794183891,6.017070689,NA,3.457858146,NA,2.24751757,3.498178681,NA,NA 2,Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC),Metabolism of RNA,5.679694811,4.756602285,3.032412212,6.75810239,5.841175721,1.316984932,5.351834747,1.562146198,5.923305204,1.151377989,2.553333478,NA,4.352372235,3.969437603,3.016721843,2.225929639,5.376629359,6.338586744,1.125346039,4.294671808,NA,2.94724998,3.149341331,1.837097799,2.603119444 3,Eukaryotic Translation Elongation,Translation,5.679694811,4.684865627,3.073628858,6.743109276,6.554557669,1.780229529,5.69965002,1.628535244,6.101369513,1.934252619,2.974944939,NA,4.696012893,4.098352769,3.668772807,3.287301495,5.48517435,6.338586744,1.59094745,5.417467716,NA,3.064288219,3.163067999,2.664317694,3.499262825 4,Eukaryotic Translation Initiation,Translation,5.679694811,4.807807579,3.065372471,6.978265822,6.614115181,1.588240845,5.69965002,1.628535244,6.320578432,1.034643435,2.33616873,NA,4.286290816,3.958312183,2.286123018,2.330582044,6.073824034,6.338586744,1.125346039,4.458873194,NA,2.518813301,3.792961364,NA,1.803107824 5,Cap-dependent Translation Initiation,Translation,5.679694811,4.807807579,3.065372471,6.978265822,6.614115181,1.588240845,5.69965002,1.628535244,6.320578432,1.034643435,2.33616873,NA,4.286290816,3.958312183,2.286123018,2.330582044,6.073824034,6.338586744,1.125346039,4.458873194,NA,2.518813301,3.792961364,NA,1.803107824 6,GTP hydrolysis and joining of the 60S ribosomal subunit,Translation,5.679694811,4.807807579,3.073628858,6.978265822,6.449305846,1.721056069,5.69965002,1.628535244,6.35123286,1.081124338,2.476629259,NA,4.286290816,3.969437603,2.934773378,2.330582044,5.847930034,6.338586744,1.189795324,4.418821037,NA,2.795297989,3.792961364,1.156934753,1.854663227 7,L13a-mediated translational silencing of Ceruloplasmin expression,Translation,5.679694811,4.807807579,3.073628858,6.978265822,6.428101819,1.721056069,5.69965002,1.628535244,6.35123286,1.189818025,2.609473756,NA,4.286290816,3.969437603,3.040363564,2.490758111,6.016164803,6.338586744,1.316274698,4.704369102,NA,2.94724998,3.792961364,1.275081112,2.078651307 8,Formation of a pool of free 40S subunits,Translation,5.5041648,4.807807579,3.032412212,6.845738204,6.614115181,1.780229529,5.69965002,1.628535244,6.35123286,1.363125434,2.974944939,NA,4.696012893,4.098352769,3.663311087,2.50824343,6.046849304,6.295278878,1.59094745,4.92357602,NA,3.064288219,3.792961364,1.846171983,2.603119444 9,rRNA processing,Metabolism of RNA,5.431495218,3.841270175,2.140837307,5.393471174,5.280984804,NA,2.906537607,NA,3.546199623,NA,1.813568113,NA,2.840092782,2.926810164,1.308714243,1.200257092,2.967451505,3.860644037,NA,4.264641883,NA,2.24751757,3.060400509,NA,1.789948773 10,Eukaryotic Translation Termination,Translation,5.415994838,4.528436165,3.032412212,6.025770982,5.96557314,1.588240845,5.274837738,1.468010953,6.097736368,1.363125434,2.752588807,NA,4.286290816,3.969437603,3.335944638,2.490758111,4.985559166,5.97674966,1.230268649,4.704369102,NA,2.947470706,3.149341331,1.975924658,2.603119444 11,Peptide chain elongation,Translation,5.391975008,4.77896878,3.032412212,6.201906044,6.614115181,1.780229529,4.844606915,1.628535244,5.61058985,1.536353493,2.609473756,NA,4.352372235,4.098352769,3.579120769,2.583187266,5.358263623,6.338586744,1.316274698,5.06911369,NA,3.064288219,2.930820016,2.069947143,2.921396903 12,SRP-dependent cotranslational protein targeting to membrane,Translation,5.391975008,4.483452822,2.397105443,5.344002772,6.297438407,1.244260975,3.835180817,1.034110636,4.795085984,NA,1.456722783,NA,2.605035311,2.657724169,2.529064474,1.241874007,4.058666155,4.684243034,NA,3.136251224,NA,2.201170016,2.670732971,1.229747959,1.704983394 13,rRNA processing in the nucleus and cytosol,Metabolism of RNA,5.226862806,3.144464995,2.397105443,5.798776149,5.420532933,NA,2.977108607,NA,3.546199623,NA,1.679200543,NA,2.728349747,2.875292917,1.247059559,1.171225903,2.817988641,4.22577574,NA,3.681702722,NA,2.260349428,2.987919712,NA,1.854663227 14,Selenocysteine synthesis,Metabolism,5.149777908,4.528436165,3.065372471,5.304953949,6.057487432,1.240217347,4.207657499,1.34495903,6.101369513,1.189818025,1.993710704,NA,4.227321376,3.554798135,3.663311087,2.330582044,4.734029171,5.563448157,NA,3.613246068,NA,2.33074931,2.846088936,1.346318784,2.603119444 15,Major pathway of rRNA processing in the nucleolus and cytosol,Metabolism of RNA,4.814815473,3.237637473,2.140837307,5.862324599,5.047168439,NA,3.517137912,NA,3.433048861,NA,1.71677079,NA,2.329777133,2.821526256,1.309351451,1.058369267,2.967451505,3.92457948,NA,3.136251224,NA,2.370619494,2.930820016,NA,1.789948773 16,Response of EIF2AK4 (GCN2) to amino acid deficiency,Cellular responses to stress,4.760937406,3.945158892,2.778138156,5.703992371,5.889781217,NA,4.63949282,NA,3.822691206,NA,1.813568113,NA,3.765087275,3.48169971,2.12591456,1.499127344,4.65439259,5.298453878,NA,3.136251224,NA,2.376466914,2.932218165,NA,1.790249276 17,Cellular response to starvation,Cellular responses to stress,4.760937406,2.842862309,1.97411103,5.217257375,4.066016561,NA,2.388625275,NA,1.81386977,NA,NA,NA,1.294189473,2.074137245,NA,NA,3.565769076,2.250896885,NA,1.442797997,NA,1.188474697,1.420848732,NA,NA 18,Selenoamino acid metabolism,Metabolism,4.316261846,3.481488693,2.440207549,4.776558106,4.832935274,NA,3.172624976,NA,3.822691206,NA,1.144825426,NA,2.840092782,2.412106091,1.764469034,2.225929639,3.137064217,4.307991111,NA,2.675319599,NA,1.75264724,2.345470856,NA,1.296336656 19,Nonsense-Mediated Decay (NMD),Metabolism of RNA,3.866782393,4.155987546,2.140837307,5.417657554,4.586429347,NA,4.517208961,NA,4.453036272,NA,NA,NA,2.329777133,2.383423112,NA,NA,4.226808989,4.111595188,NA,3.136251224,NA,2.376466914,1.814862613,NA,NA 20,Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC),Metabolism of RNA,3.866782393,4.155987546,2.140837307,5.417657554,4.586429347,NA,4.517208961,NA,4.453036272,NA,NA,NA,2.329777133,2.383423112,NA,NA,4.226808989,4.111595188,NA,3.136251224,NA,2.376466914,1.814862613,NA,NA 21,Extracellular matrix organization,Extracellular matrix organization,3.736238955,3.737849004,3.14995987,4.846594707,4.224248116,1.780229529,3.401188012,1.442102298,2.650092962,1.934252619,1.813568113,2.388998134,3.454563469,2.711510045,3.812466923,2.24465568,3.698112035,3.979463658,2.931391864,3.370181104,1.654879716,2.795297989,2.399015028,1.975924658,2.603119444 22,"Plasma lipoprotein assembly, remodeling, and clearance","Plasma lipoprotein assembly, remodeling, and clearance",-2.816197321,-3.144464995,NA,-2.315366151,-3.048033452,NA,-2.061161899,-1.365007792,-1.128374855,NA,NA,NA,NA,-1.138500898,NA,NA,-1.035147761,-2.779334943,NA,-1.26870982,NA,NA,-2.345470856,NA,NA 23,"Formation of the ternary complex, and subsequently, the 43S complex",Translation,2.240881582,1.707388815,1.618178629,3.659935603,3.12629185,1.240217347,2.231858245,NA,2.544939494,NA,NA,NA,2.447538489,1.555327959,NA,NA,3.213233234,2.779334943,NA,1.569240642,NA,1.319248099,2.065599181,NA,NA 24,Ribosomal scanning and start codon recognition,Translation,2.222867242,1.62109652,1.649976701,3.742787657,2.852656883,NA,2.529765447,NA,2.676000909,NA,NA,NA,2.114726292,1.27586056,NA,NA,2.967451505,2.557521473,NA,NA,NA,NA,1.843035978,NA,NA 25,Translation initiation complex formation,Translation,2.206677341,1.586649044,1.710687625,3.844678084,2.816833019,NA,2.563012289,NA,2.544939494,NA,NA,NA,2.114726292,1.250025548,NA,NA,3.132598785,2.45335487,NA,1.033817497,NA,NA,1.843035978,NA,NA 26,"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S",Translation,2.206677341,1.586649044,1.710687625,3.844678084,2.816833019,NA,2.563012289,NA,2.544939494,NA,NA,NA,2.114726292,1.250025548,NA,NA,3.132598785,2.45335487,NA,1.033817497,NA,NA,1.843035978,NA,NA 27,Chemokine receptors bind chemokines,Signaling by GPCR,1.71205668,1.453013876,1.314060237,1.608758007,1.906145246,NA,1.630462278,NA,2.200147232,NA,NA,NA,NA,1.555327959,NA,NA,2.20303252,1.763325567,NA,NA,NA,NA,NA,NA,NA 28,Hemostasis,Hemostasis,1.71205668,2.291848951,NA,1.608758007,1.096789956,NA,1.695404879,NA,1.050797826,NA,NA,NA,1.99025546,1.250025548,NA,NA,1.44046959,1.418835468,NA,1.026618473,NA,NA,NA,NA,NA 29,Plasma lipoprotein assembly,"Plasma lipoprotein assembly, remodeling, and clearance",-1.562126909,-1.427526483,NA,-2.912796407,-2.418670978,NA,-1.84897392,-1.272749642,-1.506088622,-1.056614038,NA,NA,-1.025802615,-1.422093721,-1.10091736,NA,-1.028305792,-1.510415351,-1.125346039,-1.605069273,NA,-1.035489274,-2.043189447,-1.176735248,NA 30,Plasma lipoprotein clearance,"Plasma lipoprotein assembly, remodeling, and clearance",-1.558060657,-1.54383424,NA,-1.073387873,-1.314342483,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,-1.967894381,NA,NA,NA,NA,-1.657889502,NA,NA 31,Plasma lipoprotein remodeling,"Plasma lipoprotein assembly, remodeling, and clearance",-1.448597612,-2.111594473,NA,-1.529420792,-2.358118861,NA,-1.94215279,NA,NA,NA,NA,NA,NA,NA,-1.352403655,NA,NA,-1.31957469,NA,NA,NA,NA,NA,-1.021938502,NA 32,Signaling by Interleukins,Cytokine Signaling in Immune system,1.425507282,1.586649044,NA,1.601295586,1.314342483,NA,1.84897392,NA,1.147751374,NA,NA,NA,NA,1.094610087,NA,NA,NA,1.488633863,NA,NA,NA,NA,NA,NA,NA 33,Prefoldin mediated transfer of substrate to CCT/TriC,Translation,1.419731481,1.514610222,NA,1.113526737,1.377751613,NA,1.178201917,NA,1.050797826,NA,NA,NA,NA,NA,NA,NA,1.549484876,1.099246377,NA,NA,NA,NA,NA,NA,NA 34,Syndecan interactions,Extracellular matrix organization,1.419731481,NA,NA,1.113526737,NA,NA,2.061837361,1.070369214,1.007195282,1.189818025,1.077642296,NA,1.253545713,1.175639745,1.174908467,1.56374891,NA,1.18173221,1.316274698,NA,NA,1.035489274,1.058840945,NA,NA 35,Gap junction assembly,Gap junction trafficking and regulation,1.371531945,2.823150952,NA,1.128245966,2.823920102,NA,NA,1.468010953,NA,NA,1.256732857,NA,NA,1.380111643,NA,NA,1.16221441,1.877706685,NA,1.083467713,NA,1.204524443,NA,NA,NA 36,Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding,Translation,1.303632265,1.653901876,NA,1.309799492,1.536576605,NA,1.254626856,NA,1.24167251,NA,NA,NA,1.025802615,NA,NA,NA,1.52437766,1.292974424,NA,NA,NA,NA,NA,NA,NA 37,Formation of tubulin folding intermediates by CCT/TriC,Translation,1.29503613,1.608361332,NA,1.113526737,1.594951795,NA,NA,NA,1.000108351,NA,NA,NA,NA,NA,NA,NA,1.481944111,NA,NA,NA,NA,NA,NA,NA,NA 38,Mitochondrial Fatty Acid Beta-Oxidation,Metabolism of lipids,-1.199446022,NA,NA,-1.049251006,NA,NA,-1.225155232,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA 39,Gap junction trafficking,Gap junction trafficking and regulation,1.189851876,1.707388815,NA,1.083570591,1.9278736,NA,NA,NA,1.128374855,NA,1.188781116,NA,1.305102759,NA,NA,NA,NA,2.097208581,NA,NA,NA,NA,NA,NA,NA 40,ECM proteoglycans,Extracellular matrix organization,1.127711323,NA,1.160010741,NA,1.16585703,NA,1.35133092,1.311715086,1.248157155,1.189818025,1.24929839,NA,1.761398758,1.407737112,1.665869629,NA,1.112892102,1.113341834,1.125346039,1.774488272,NA,NA,NA,1.846171983,1.664198171 41,Fatty acid metabolism,Metabolism of lipids,-1.125898123,NA,NA,-1.790873095,NA,NA,-1.832553559,NA,NA,NA,-1.077642296,NA,NA,NA,-1.636569451,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA 42,Non-integrin membrane-ECM interactions,Extracellular matrix organization,1.123532302,NA,NA,1.309799492,1.236669586,NA,1.320839244,NA,1.292888732,1.363125434,NA,NA,1.487696361,1.422093721,NA,1.39431953,NA,1.085485897,1.316274698,NA,NA,NA,1.657889502,1.021938502,1.127227351 43,Elastic fibre formation,Extracellular matrix organization,1.100410248,NA,NA,1.608758007,NA,NA,NA,NA,NA,NA,NA,NA,1.452395034,1.175639745,1.111425673,NA,1.16221441,NA,NA,NA,NA,NA,NA,NA,NA 44,Interleukin-4 and Interleukin-13 signaling,Cytokine Signaling in Immune system,1.030175387,NA,1.021824353,1.367935627,1.228244138,NA,NA,NA,1.242592225,NA,NA,NA,NA,1.27586056,NA,NA,NA,1.292974424,NA,1.042203499,NA,NA,NA,NA,NA 45,Gap junction trafficking and regulation,Gap junction trafficking and regulation,1.01965267,1.573122308,NA,NA,1.511396239,NA,NA,NA,NA,NA,1.278543791,NA,NA,1.185787208,NA,NA,NA,2.011618865,NA,NA,NA,NA,NA,NA,NA 46,"Signaling by Rho GTPases, Miro GTPases and RHOBTB3",Signal Transduction,1.01965267,1.032365275,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,1.65527061,NA,NA,NA,1.524412159,NA,1.746894695,NA,NA,1.539270468,NA,1.153096392 47,Binding and Uptake of Ligands by Scavenger Receptors,Binding and Uptake of Ligands by Scavenger Receptors,NA,-2.160977555,NA,-1.590786812,-1.073554781,-1.780229529,NA,-1.628535244,-1.007195282,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,-1.605069273,NA,NA,NA,NA,-1.807879652 48,Formation of the cornified envelope,Keratinization,NA,1.493336351,NA,2.530502965,1.271777827,NA,1.388602239,NA,2.748356411,NA,1.813568113,NA,NA,1.323643538,NA,1.326379657,1.120319919,1.663717158,1.325368359,NA,NA,NA,1.419562927,NA,NA 49,Scavenging by Class A Receptors,Binding and Uptake of Ligands by Scavenger Receptors,NA,-1.424449511,NA,-1.002970431,NA,-1.193690779,NA,-1.426699846,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA 50,RHO GTPase cycle,Signaling by Rho GTPases,NA,1.406908481,NA,NA,1.488932105,NA,NA,1.395840263,NA,1.189818025,NA,NA,NA,1.566780758,1.195252376,1.561357933,NA,2.574846331,NA,1.491834923,NA,1.005980566,1.516196525,NA,1.131747616 51,Keratinization,Keratinization,NA,1.352323437,NA,2.378304933,NA,NA,1.137556814,NA,1.179629727,1.000372924,1.207559293,NA,NA,NA,NA,1.235844206,NA,NA,1.316274698,NA,NA,NA,1.117919547,NA,1.105222901 52,Xenobiotics,Metabolism,NA,1.093770061,1.314060237,NA,1.228112461,NA,NA,NA,1.312377196,NA,NA,NA,NA,NA,NA,1.384122341,2.241262458,NA,NA,NA,NA,NA,NA,NA,NA 53,Neuronal System,Neuronal System,NA,-1.093770061,-1.31052219,NA,NA,NA,-1.090516862,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA 54,Signaling by Rho GTPases,Signaling by Rho GTPases,NA,1.032365275,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,1.664585556,NA,NA,NA,1.877706685,NA,1.77365814,NA,NA,1.967052951,NA,NA 55,Cell-extracellular matrix interactions,Cell-Cell communication,NA,NA,NA,1.429851242,NA,1.030562959,1.346048281,NA,NA,1.000372924,1.514065576,NA,1.102315381,1.080181446,1.570701024,NA,NA,1.889714893,1.21749075,NA,1.096158935,1.357134348,1.345685648,1.121120563,1.127227351 56,Metabolism of lipids,Metabolism of lipids,NA,NA,NA,-1.37250763,NA,NA,-1.551379544,NA,NA,-1.031524285,NA,NA,NA,NA,-1.553403338,NA,NA,NA,-1.316274698,NA,NA,NA,NA,NA,NA 57,Class A/1 (Rhodopsin-like receptors),Signaling by GPCR,NA,NA,NA,NA,NA,NA,1.084772266,NA,NA,NA,1.482842523,NA,NA,NA,1.195252376,NA,NA,NA,1.125346039,NA,NA,NA,1.112481048,1.021938502,1.105222901