Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

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Uwe Marx
Tommy B. Andersson
Anthony Bahinski
Mario Beilmann
Sonja Beken
Flemming R. Cassee
Murat Cirit
Mardas Daneshian
Susan Fitzpatrick
Olivier Frey
Claudia Gaertner
Christoph Giese
Linda Griffith
Thomas Hartung
Minne B. Heringa
Julia Hoeng
Wim H. de Jong
Hajime Kojima
Jochen Kuehnl
Marcel Leist
Andreas Luch
Ilka Maschmeyer
Dmitry Sakharov
Adrienne J. A. M. Sips
Thomas Steger-Hartmann
Danilo A. Tagle
Alexander Tonevitsky
Tewes Tralau
Sergej Tsyb
Anja van de Stolpe
Rob Vandebriel
Paul Vulto
Jufeng Wang
Joachim Wiest
Marleen Rodenburg
Adrian Roth


The recent advent of microphysiological systems – microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation in vitro – promises to enable a global paradigm shift in drug development. An extraordinary US government initiative and various dedicated research programs in Europe and Asia recently have led to the first cutting-edge achievements of human single-organ and multi-organ engineering based on microphysiological systems. The expectation is that test systems established on this basis will model various disease stages and predict toxicity, immunogenicity, ADME profiles and treatment efficacy prior to clinical testing. Consequently, this technology could significantly affect the way drug substances are developed in the future. Furthermore, microphysiological system-based assays may revolutionize our current global programs of prioritization of hazard characterization for any new substances to be used, for example, in agriculture, food, ecosystems or cosmetics, thus replacing the use of laboratory animal models. Here, thirty-six experts from academia, industry and regulatory bodies present the results of an intensive workshop (held in June 2015, Berlin, Germany). They review the status quo of microphysiological systems available today against industry needs, and assess the broad variety of approaches with fit-for-purpose potential in the drug development cycle. Feasible technical solutions to reach the next levels of human biology in vitro are proposed. Furthermore, key organ-on-a-chip case studies as well as various national and international programs are highlighted. Finally, a roadmap into the future towards more predictive and regulatory-accepted substance testing on a global scale is outlined.

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Marx, U., Andersson, T. B., Bahinski, A., Beilmann, M., Beken, S., Cassee, F. R., Cirit, M., Daneshian, M., Fitzpatrick, S., Frey, O., Gaertner, C., Giese, C., Griffith, L., Hartung, T., Heringa, M. B., Hoeng, J., de Jong, W. H., Kojima, H., Kuehnl, J., Leist, M., Luch, A., Maschmeyer, I., Sakharov, D., Sips, A. J. A. M., Steger-Hartmann, T., Tagle, D. A., Tonevitsky, A., Tralau, T., Tsyb, S., van de Stolpe, A., Vandebriel, R., Vulto, P., Wang, J., Wiest, J., Rodenburg, M. and Roth, A. (2016) “Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing”, ALTEX - Alternatives to animal experimentation, 33(3), pp. 272–321. doi: 10.14573/altex.1603161.

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