[Local reactions after the application of several adjuvants in chicken] [Article in German]

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Published: Jan 1, 1996

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Peter Schmidt
Institut für Tierpathologie der Ludwig-Maximilians-Universität, D-München
Michael Erhard
Institut für Physiologie, Physiologische Chemie und Tierernährung der Ludwig-Maximilians-Universität, D-München
Rüdiger Wanke
Institut für Tierpathologie der Ludwig-Maximilians-Universität, D-München
Andrea Hofmann
Institut für Physiologie, Physiologische Chemie und Tierernährung der Ludwig-Maximilians-Universität, D-München
Wolfgang Schmahl
Institut für Tierpathologie der Ludwig-Maximilians-Universität, D-München

Abstract

For an animal sparing adjuvant high immunostimulation potential combined with minimum tissue irritating qualities are to be demanded. In the present study local tissue reaction due to intramuscular injection of Freund's complete adjuvant (FCA), muramyl-dipeptide (MDP) and Pam3Cys-Ser-(Lys) 4 (PCSL) into the pectoral muscle of hens was examined. After application of FCA in all cases there was a violent tissue reaction resulting in a pronounced granulomatous, in some cases absceding, inflammation. The use of MDP and of the synthetic lipopeptide PCSL provoked only a mild and transient tissue reaction. Therefore and because of its high immunostimulation potential, PCSL is a convenient alternative to FCA.

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How to Cite
Schmidt, P., Erhard, M., Wanke, R., Hofmann, A. and Schmahl, W. (1996) “[Local reactions after the application of several adjuvants in chicken] [Article in German]”, ALTEX - Alternatives to animal experimentation, 13(Supp. 1), pp. 30–34. Available at: https://www.altex.org/index.php/altex/article/view/2058 (Accessed: 3 June 2023).
Issue
Vol. 13 No. Supp. 1 (1996): Egg yolk antibodies, IgY technology
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Articles
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