Proceedings of the 7th World Congress, Rome 2009

Main Article Content

Franz P. Gruber

Abstract

Congress Chairmen´s Preface


Thomas Hartung and Herman Koeter


 


Contents


 


PLENARY LECTURES


PL3 Ingrid E. Newkirk: Brueghel̓s two monkeys: passing the final exam in the history of mankind


PL7 Michalel Balls: The principles of humane experimental technique: timeless insights and unheeded warnings


Alan M. Goldberg: The principles of humane experimental technique: is it relevant today?


PL8 Melvin E. Andersen: Calling on science: making alternatives the new “gold” standard


 


EARLY MORNING SESSIONS


MS3 Animal welfare associations


Stefanie Schindler: Foundation Animalfree Research: 33 years of commitment to alternatives to animal experiments


 


MS5 3R centers


Carol J. Howard: CAAT: a 3Rs center for the 21st century


Octavio Presgrave, Chantra Eskes, Rosaura Presgrave, Eloisa Alves, João Carlos Freitas, Cristiane Caldeira, Izabela Gimenes, Ronald Silva, Saulo Nogueira, Jadir Nunes, Ekaterina Rivera, Vanessa, Sá-Rocha, Sandra Coecke and Thomas Hartung: A proposal of establishing a brazilian center for validation of alternative methods (BraCVAM)


Mohammad A. Akbarsha, Shiranee Pereira and Franz P. Gruber: A national center for animal alternatives in India: the Mahatma Gandhi-Doerenkamp Center for alternatives to the use of animals in life science education (MGDC)


 


MS6 Associations


Isabella De Angelis, Simonetta Gemma and Francesca Caloni: CELLTOX: the Italian association for in vitro toxicology


 


MS8 Industry activities


Carl Westmoreland, Paul Carmichael, Matt Dent, Julia Fentem, Cameron MacKay, Gavin Maxwell, Camilla Pease and Fiona Reynolds: Assuring safety without animal testing: Unilever’s ongoing research programme to deliver novel ways to assure consumer safety


Annamaria A. Bottini and Thomas Hartung: The economics of animal testing


 


THEME 1: Innovative technologies, concepts and approaches


 


Breakout Sessions


BS6 Non-vertebrate models


Windy A. Boyd and Jonathan H. Freedman: Medium and high-throughput toxicity screens using C. elegans


 


BS10 Current and evolving concepts for the validation of safety assessment methods


William S. Stokes and Marilyn Wind: Validation of innovative technologies and strategies for regulatory safety assessment methods: challenges and opportunities


Marilyn Wind and William S. Stokes: Developing performance standards to expedite validation of innovative and improved test methods


 


Extra Breakout Sessions


EB1 Status report on Predict-IV


Frédéric Y. Bois, Dany Habka and Céline Brochot: An integrated modelling approach for in vitro to in vivo extrapolations


 


EB3 Status report on CAESAR


Anna Lombardo, Rodolfo Gonella Diaza, Alessandra Roncaglioni and Emilio Benfenati: CAESAR’s approach for alternative in silico methods for REACH


Giuseppina Gini, Thomas Ferrari, Alessandra Roncaglioni: The in silico model for mutagenicity


Mark T. D. Cronin, Steven J. Enoch, Mark Hewitt and Judith C. Madden: Formation of mechanistic categories and local models to facilitate the prediction of toxicity


 


Lunch Sessions


SL1 Databases: progress report


Daniel Butzke, Antje Doerendahl, Susanne Skolik, Andreas Luch and Barbara Grune: The AnimALT-ZEBET Database: A unique resource for comprehensive and value-added information on 3R alternatives


Martin Stephens and Sherry L. Ward: AltTox.org: Connecting stakeholders on issues concerning non-animal methods of toxicity testing


 


SL2 Good Cell Culture Practices


Gerhard Gstraunthaler: The Bologna Statement on Good Cell Culture Practice (GCCP) – 10 years later


 


THEME 2: Areas of animal use


 


Breakout Sessions


BS11 Basic research


Randall J. Nelson: Viable alternatives: choosing the proper experimental model for neuroscience studies


Mathieu Vinken, Elke Decrock, Luc Leybaert, Tamara Vanhaecke and Vera Rogiers: Proteolytic cleavage of adherens junction components during Fas-dependent cell death in primary cultures of rat hepatocytes


 


BS12 Chemicals and pesticides


Bennard van Ravenzwaay: Initiatives to decrease redundancy in animal testing of pesticides


 


BS13 Cosmetics


Gavin Maxwell, Pierre Aeby, Takao Ashikaga, Sandrine Bessou-Touya, Walter Diembeck, Frank Gerberick, Petra Kern, Monique Marrec-Fairley, Jean-Marc Ovigne, Hitoshi Sakaguchi, Klaus Schroeder, Magali Tailhardat, Silvia Teissier and Petra Winkler: Skin Sensitisation: the Colipa strategy for developing and evaluating non-animal test methods for risk assessment


 


BS19 Education and training


Jan van der Valk, Marilyn Brown, Clément Gauthier, Brian Howard, Tsutomu Miki Kurosawa, Margaret Rose and Bert van Zutphen: Education and training in the 3Rs


Bryan Howard and Patri Vergara: FELASA category C courses


 


BS20 Animal use policies


Joerg Luy: Animal experiments – the principle of proportionality as key principle of ethical evaluation


Maggy Jennings: Special protection for primates – the need for faster progress


Gilly Griffin, Nicole Fenwick, Elisabeth Ormandy and Clément Gauthier: Applying information gained from animal impact categorization systems – case study of Canada’s categories of invasiveness


David J. Mellor, Tamara J. Diesch and Craig B. Johnson: Should mammalian fetuses be excluded from regulations protecting animals during experiments?


Virginia M. Williams and Linda A. Carsons: Reviewing the reviews: an analysis of the process of ensuring regulatory compliance in the use of animals in science in New Zealand


 


Extra Breakout Sessions


EB4 Status report on ICATM


Marilyn Wind, David Blakey, Hajime Kojima, Joachim Kreysa and William Stokes: The International Cooperation on Alternative Test Methods (ICATM)


William S. Stokes and Marilyn Wind: NICEATM and ICCVAM participation in the international cooperation on alternative test methods


 


Lunch Sessions


SL4 William Stokes and Marilyn Wind: Recent progress and future directions in the validation and regulatory acceptance of alternative test methods that reduce, refine and replace animal use


 


THEME 3: Progress in life science domains


 


Breakout Sessions


BS21 Skin and eye toxicity


Natsch, Andreas: Mechanistic assays for the in vitro prediction of skin sensitization: Integrating biological and chemical measurements in a holistic approach


Marleen Pauwels and Vera Rogiers: In Vitro dermal toxicity testing of cosmetic ingredients: an iterative approach to complete regulatory acceptance


 


BS22 Skin and eye toxicity 2


Valérie Zuang, João Barroso, Thomas Cole, Mara Ceridono and Chantra Eskes: ECVAM Bottom-Up/Top-Down Testing approach: testing strategy to reduce/replace the Draize eye test and validation/regulatory acceptance of in vitro assays: current status


Yulia Kaluzhny, Helena Kandarova, Patrick Hayden, Joseph Kubilus, Laurence d’Argembeau-Thornton and Mitchell Klausner: ECVAM drives expanded EpiOcular applicability domain for EU legislation: successful international pre-validation.


Stuart J Freeman, Nathalie Alépée, João Barroso, Thomas Cole, Anna Compagnoni, Carina de Jong-Rubingh,Chantra Eskes, Jan Lammers, Pauline McNamee, Uwe Pfannenbecker and Valérie Zuang: Prospective validation study of reconstructed human tissue models for eye irritation testing


 


BS24 Genotoxicity and carcinogenicity


Philippe Vanparys, Raffaella Corvi, Leonard Schechtman, Marilyn Aardema, Makoto Hayashi and Sebastian Hoffman: ECVAM validation of three cell transformation assays


 


BS26 Disease models


Karl A. Andrutis: Refining clinical care in animal disease models


 


BS27 Environmental science


Mark T. D. Cronin: Use of mode and mechanism of action information to support in silico prediction of ecotoxicity


 


BS28 Animal welfare science


David J. Mellor, Tamara J. Diesch and Craig B. Johnson: When do mammalian young become sentient?


Margaret Rose: International perspectives on animal welfare: initiatives to harmonise approaches when animals used for scientific purposes.


Derek Fry, Rose Gaines Das, Richard Preziosi and Michelle Hudson: Planning for refinement and reduction


 


BS29 Immunology


Stefan F. Martin and P. R. Esser: Innate immune mechanisms in contact dermatitis and the resulting T cell responses


 


BS30 Neuroscience


Lucio G. Costa, Gennaro Giordano and Marina Guizzetti: In vitro models to study cell-cell interactions that influence developmental neurotoxicity


 


Extra Breakout Sessions


EB7 Status report on OSIRIS


Romualdo Benigni, Cecilia Bossa, Alessandro Giuliani, and Olga Tcheremenskaia: In vitro/in vivo relationship in the light of Toxcast Phase


 


EB10 Status report on Sens-it-iv


Stefan F. Martin, Andrea Cavani, Enrico Maggi, Hermann-Josef Thierse, Anne Richter and Federica Sallusto: T-cell priming and amplification: exploiting key events in contact sensitization


 


Satellite Meeting


A satellite symposium to the 7th World Congress on Alternatives and Animal Use in the Life Sciences, organized under auspices of CELLTOX (Associazione Italiana di Tossicologia in vitro) and ESTIV (European Society of Toxicology in Vitro)


Introduction


Francesca Caloni, Isabella De Angelis and Jan van der Valk: From tissue engineering to alternatives: research, discovery and development


Abdoelwaheb El Ghalbzouri and Suzan Commandeur: In vitro disease models: human skin equivalents for research purposes


Giovanna Mazzoleni and Nathalie Steimberg: 3D culture in microgravity: a realistic alternative to experimental animal use


Dong-Hyuk Park, Alison E. Willing, Svitlana Garbuzova-Davis, Jun Tan, Cesario V. Borlongan, Nicole Kuzmin-Nichols, L. Eduardo Cruz and Paul R. Sanberg: The emerging field of human umbilical cord blood cell transplantation


 


Authors Register


Imprint

Article Details

How to Cite
Gruber, F. P. (2010) “Proceedings of the 7th World Congress, Rome 2009”, ALTEX - Alternatives to animal experimentation, 27(Supp), pp. 1-335. Available at: https://www.altex.org/index.php/altex/article/view/2214 (Accessed: 26October2021).
Section
Editorial