Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens

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Sylvia E. Escher
Susan P. Felter
Heli Hollnagel
Alan R. Boobis
Chihae Yang
James Rathman
Mark T. D. Cronin
Monika Batke

Abstract

Threshold of toxicological concern (TTC) values are frequently used for compounds occurring at low concentrations in feed and food or as impurities in drugs. This workshop report addresses the emerging alternatives for deriving TTC values for DNA reactive carcinogens and evaluating the acceptability of the Cramer Class TTC values to be adequately protective for non-DNA reactive carcinogens.

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How to Cite
Escher, S. E., Felter, S. P., Hollnagel, H., Boobis, A. R., Yang, C., Rathman, J., Cronin, M. T. D. and Batke, M. (2022) “Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens”, ALTEX - Alternatives to animal experimentation. doi: 10.14573/altex.2210111.
Section
Meeting Reports
References

References

Batke, M., Afrapoli, F. M., Kellner, R. et al. (2021). Threshold of toxicological concern - an update for non-genotoxic carcinogens. Front Toxicol. 3, 688321. doi:10.3389/ftox.2021.688321

Boobis, A., Brown, P., Cronin, M. T. D. et al. (2017). Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation. Crit Rev Toxicol. 47, 705–727. doi:10.1080/10408444.2017.1318822

Cheeseman, M., Machuga, E. and Bailey, A. (1999). A tiered approach to threshold of regulation. Food Chem Toxicol 37, 387-412. doi:10.1016/s0278-6915(99)00024-1

Cramer, G. M., Ford, R. A., Hall, R. L. (1976). Estimation of toxic hazard—A decision tree approach. Food Cosmet Toxicol 16, 255-276. doi:10.1016/S0015-6264(76)80522-6

Cross, K. P., Ponting, D. J. (2021). Developing structure-activity relationships for N-nitrosamine activity. Comput Toxicol 20,100186. doi:10.1016/j.comtox.2021.100186

EFSA (2009). Guidance of the Scientific Committee on Use of the benchmark dose approach in risk assessment. EFSA J 7, 1150. doi:10.2903/j.efsa.2009.1150

EFSA (2012). Scientific opinion on exploring options for providing advice about possible human health risks based on the concept of threshold of toxicological concern (TTC). EFSA J 10, 2750. doi:10.2903/j.efsa.2012.2750

EFSA Scientific Committee, Hardy, A., Benford, D. et al. (2017). Update: Guidance on the use of the benchmark dose approach in risk assessment. EFSA J 15, 4658. doi:10.2903/j.efsa.2017.4658

EFSA Scientific Committee, More, S. J., Bampidis, V., et al. (2019). Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment. EFSA J 17, e05708. doi:10.2903/j.efsa.2019.5708

EFSA and WHO (2016). Review of the threshold of toxicological concern (TTC) approach and development of new TTC decision tree. EFSA supporting publication. doi:10.2903/sp.efsa.2016.EN-1006

Ellison, C. A., Api, A. M., Becker, R. A. et al. (2020). Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future. Front Toxicol. 2, 621541. doi:10.3389/ftox.2020.621541

Hardy, A., Benford, D., Halldorsson, T. et al. (2017). Update: use of the benchmark dose approach in risk assessment. EFSA 15, e04658. doi:10.2903/j.efsa.2017.4658

Kobets, T. and Williams, G. M. (2019). Review of the evidence for thresholds for DNA-Reactive and epigenetic experimental chemical carcinogens. Chem Biol Interact 301, 88-111. doi:10.1016/j.cbi.2018.11.011

Kroes, R., Renwick, A. G., Cheeseman, M. et al. (2004). Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet. Food Chem Toxicol 42, 65-83. doi:10.1016/j.fct.2003.08.006

Munro, I. C., Ford, R. A., Kennepohl, E. and Sprenger, J. G. (1996). Correlation of structural class with no-observed-effect levels: A proposal for establishing a threshold of concern. Food Chem Toxicol 34, 829-867. doi:10.1016/S0278-6915(96)00049-X

Preston, R. J. and Williams, G. M. (2005). DNA-reactive carcinogens: mode of action and human cancer hazard. Crit Rev Toxicol 35, 673-683. doi:10.1080/10408440591007278

Russell, W. M. S. (1999). The principles of humane experimental technique. Special ed. Wheathampstead: Universities Federation for Animal Welfare. ISBN: 0900767782.

WHO (2020). Principles and methods for the risk assessment of chemicals in food: Section 4.5. 2nd Edition. Geneva: World Health Organization. ISBN: 9789241572408.

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