Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

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Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Martin Paparella
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Schaffert, A., Murugadoss, S., Mertens, B. . and Paparella, M. (2023) “Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs”, ALTEX - Alternatives to animal experimentation, 40(2), pp. 337–340. doi: 10.14573/altex.2301121.
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Letter
Author Biography

Birgit Mertens, Scientific Direction of Chemical and Physical Health Risks, Sciensano, Brussels, Belgium; Department of Pharmaceutical Sciences, Universiteit Antwerpen, Wilrijk, Belgium

 

 

References

Bopp, S. K., Kienzler, A., Richarz, A. N. et al. (2019). Regulatory assessment and risk management of chemical mixtures: Challenges and ways forward. Crit Rev Toxicol 49, 174-189. doi:10.1080/10408444.2019.1579169

Burnett, S. D., Blanchette, A. D., Chiu, W. A. et al. (2021). Cardiotoxicity hazard and risk characterization of ToxCast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors. Chem Res Toxicol 34, 2110-2124. doi:10.1021/acs.chemrestox.1c00203

Daley, M. C., Mende, U., Choi, B. R. et al. (2023). Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing. ALTEX 40, 103-116. doi:10.14573/altex.2109131

ECHA (2017). Guidance on the Biocidal Products Regulation: Volume III Human Health – Assessment & Evaluation (Parts B+C).

EU (2006). Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006. https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2007:136:0003:0280:en:pdf (accessed 01.09.2022)

EU (2009). Regulation (EC) No 1107/2009 of the European Parliament and of the Council of 21 October 2009. https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:309:0001:0050:en:pdf (accessed 01.09.2022)

EU (2012). Regulation (EU) No 528/2012 of the European Parliament and of the Council of 22 May 2012. https://eur-lex.europa.eu/legal-content/en/txt/pdf/?uri=celex:32012R0528 (accessed 01.09.2022)

Kemikalieinspektionen (2021). PM 8/21: Improving the regulatory assessment of combination effects: Steps towards implementing the mixture assessment factor (MAF) in chemical regulation. https://bit.ly/3mqMidA (accessed 25.11.2022)

Krishna, S., Berridge, B. and Kleinstreuer, N. (2021). High-throughput screening to identify chemical cardiotoxic potential. Chem Res Toxicol 34, 566-583. doi:10.1021/acs.chemrestox.0c00382

OECD (2017). Chemical Safety Assessment Workflow Based on Exposure Considerations and Non-Animal Methods. Series on Testing and Assessment, No. 275. OECD Publishing, Paris. https://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono(2017)27&doclanguage=en

OECD (2022). OECD Test Guidelines for Chemicals. https://www.oecd.org/chemicalsafety/testing/oecdguidelinesforthetestingofchemicals.htm (accessed 05.07.2022)

Paparella, M., Colacci, A. and Jacobs, M. N. (2017). Uncertainties of testing methods: What do we (want to) know about carcinogenicity? ALTEX 34, 235-252. doi:10.14573/altex.1608281

Paparella, M., Bennekou, S. H. and Bal-Price, A. (2020). An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches. Reprod Toxicol 96, 327-336. doi:10.1016/j.reprotox.2020.08.002

WHO – World Health Organization (2018). Guidance Document on Evaluating and Expressing Uncertainty in Hazard Characterization The International Programme on Chemical Safety. https://www.who.int/publications/i/item/9789241513548

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