Pathway-based toxicity: History, current approaches, and liver fibrosis and steatosis as prototypes

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Catherine Willett
Jessica Caverly Rae
Katy O. Goyak
Brigitte Landesmann
Gary Minsavage
Carl Westmoreland

Abstract

The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report, Toxicity Testing in the 21st Century: a Vision and a Strategy. The HTPC held a workshop, “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action,” in January, 2013, in Baltimore, MD, to further the science of pathway-based approaches to liver toxicity. This review was initiated as a thought-starter for this workshop and has since been updated to include insights from the workshop and other activities occurring in 2013. The report of the workshop has been published in the same issue of this journal (Willett et al., 2014).

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How to Cite
[1]
Willett, C., Caverly Rae, J., Goyak, K., Landesmann, B., Minsavage, G. and Westmoreland, C. 2014. Pathway-based toxicity: History, current approaches, and liver fibrosis and steatosis as prototypes. ALTEX - Alternatives to animal experimentation. 31, 4 (Nov. 2014), 407-421. DOI:https://doi.org/10.14573/altex.1401283.
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