The SCAHT Adverse Outcome Pathway (AOP)_HUB: A hands-on platform for information exchange, sharing, and developing AOPs

Meeting Reports

Bajard, L., Adamovsky, O., Audouze, K. et al. (2023). Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations. Environ Res 217, 114650. doi:10.1016/j.envres.2022.114650

Bal-Price, A., Crofton, K. M., Sachana, M. et al. (2015). Putative adverse outcome pathways relevant to neurotoxicity. Crit Rev Toxicol 45, 83-91. doi:10.3109/10408444.2014.981331

Carusi, A., Davies, M. R., De Grandis, G. et al. (2018). Harvesting the promise of AOPs: An assessment and recommendations. Sci Total Environ 628-629, 1542-1556. doi:10.1016/j.scitotenv.2018.02.015

Edwards, S. W., Tan, Y.-M., Villeneuve, D. L. et al. (2016). Adverse outcome pathways – Organizing toxicological information to improve decision making. J Pharmacol Exp Ther 356, 170-181. doi:10.1124/jpet.115.228239

EFSA PPR Panel – EFSA Panel on Plant Protection Products and their Residues, Hernández-Jerez, A., Adriaanse, P. et al. (2021). Development of integrated approaches to testing and assessment (IATA) case studies on developmental neurotoxicity (DNT) risk assessment. EFSA J 19, e06599. doi:10.2903/j.efsa.2021.6599

FitzGerald, R. E. (2020). Adverse outcome pathway bridge building from research to regulation. Chem Res Toxicol 33, 849-851. doi:10.1021/acs.chemrestox.9b00527

JRC – European Commission: Joint Research Centre, Wittwehr, C., Audouze, K. et al. (2025). SKIG Report 2023-2024. Publications Office of the European Union, Luxembourg. JRC140403. https://data.europa.eu/doi/10.2760/7749010

Mortensen, H. M., Senn, J., Levey, T. et al. (2021). The 2021 update of the EPA’s adverse outcome pathway database. Sci Data 8, 169. doi:10.1038/s41597-021-00962-3

OECD (2017). Guidance Document for the Use of Adverse Outcome Pathways in Developing Integrated Approaches to Testing and Assessment (IATA). OECD Series on Testing and Assessment, No. 260. OECD Publishing, Paris. doi:10.1787/44bb06c1-en

OECD (2018). Users’ Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways. OECD Series on Adverse Outcome Pathways, No. 1. OECD Publishing, Paris. doi:10.1787/5jlv1m9d1g32-en

Perkins, E., Garcia-Reyero, N., Edwards, S. et al. (2015). The adverse outcome pathway: A conceptual framework to support toxicity testing in the twenty-first century. In J. Hoeng and M. C. Peitsch (eds), Computational Systems Toxicology (1-26). New York, NY, USA: Springer. doi:10.1007/978-1-4939-2778-4_1

Svingen, T., Villeneuve, D. L., Knapen, D. et al. (2021). A pragmatic approach to adverse outcome pathway development and evaluation. Toxicol Sci 184, 183-190. doi:10.1093/toxsci/kfab113

Villeneuve, D. L., Crump, D., Garcia-Reyero, N. et al. (2014a). Adverse outcome pathway (AOP) development I: Strategies and principles. Toxicol Sci 142, 312. doi:10.1093/toxsci/kfu199

Villeneuve, D. L., Crump, D., Garcia-Reyero, N. et al. (2014b). Adverse outcome pathway development II: Best practices. Toxicol Sci 142, 321-330. doi:10.1093/toxsci/kfu200

Vinken, M. (2013). The adverse outcome pathway concept: A pragmatic tool in toxicology. Toxicology 312, 158-165. doi:10.1016/j.tox.2013.08.011

Vinken, M., Knapen, D., Vergauwen, L. et al. (2017). Adverse outcome pathways: A concise introduction for toxicologists. Arch Toxicol 91, 3697-3707. doi:10.1007/s00204-017-2020-z

Willett, C., Fitzpatrick, S., Meek, B. et al. (2018). Use of adverse outcome pathways in human risk assessment and toxicology. In N. Garcia-Reyero and C. A. Murphy (eds), A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment (349-378). Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-66084-4_17