Editorial

U2

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Food for Thought ...

Look back in anger – what clinical studies tell us about preclinical work

Thomas Hartung

275-291

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Articles

In vitro pituitary and thyroid cell proliferation assays and their relevance as alternatives to animal testing

Barae Jomaa, Jac M. M. J. G. Aarts, Laura H. J. de Haan, Ad A. C. M. Peijnenburg, Toine Bovee, Albertinka J. Murk, Ivonne M. C. M. Rietjens

293-307

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In vitro to human in vivo translation – pharmacokinetics and pharmacodynamics of quinidine

Sebastian Polak

309-318

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Predictive value of cell assays for developmental toxicity and embryotoxicity of conazole fungicides

Karin Dreisig, Camilla Taxvig, Mia Birkhøj Kjærstad, Christine Nellemann, Ulla Hass, Anne Marie Vinggaard

319-330

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In vitro metabolism and bioavailability tests for endocrine active substances: What is needed next for regulatory purposes?

Miriam N. Jacobs, Susan C. Laws, Kate Willett, Pat Schmieder, Jenny Odum

331-351

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In vitro testicular toxicity models: Opportunities for advancement via biomedical engineering techniques

Louise Parks Saldutti, Bruce K. Beyer, William Breslin, Terry R. Brown, Robert E. Chapin, Brian Enright, Elaine Faustman, Paul M. D. Foster, Thomas Hartung, William Kelce, James H. Kim, Elizabeth G. Loboa, Aldert H. Piersma, David Seyler, Katie J. Turner, Hanry Yu, Xiaozhong Yu, Jennifer C. Sasaki

353-377

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Meeting Reports

Alternative methods: 3Rs, research and regulatory aspects

Francesca Caloni, Patrizia Costa, Gianni Dal Negro, Isabella De Angelis, Silvia Dotti, Giovanna Lazzari, Giacomo Metteucci, Augusto Vitale

378-380

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Comments

Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Daniel R. Dietrich, Sonja von Aulock, Hans Marquardt, Bas Blaauboer, Wolfgang Dekant, James Kehrer, Jan Hengstler, Abby Collier, Gio Batta Gori, Olavi Pelkonen, Florian Lang, Frans P. Nijkamp, Kerstin Stemmer, Albert Li, Kai Savolainen, A. Wallace Hayes, Nigel Gooderham, Alan Harvey

381-385

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Bayesian Network Integrated Testing Strategy and beyond

Federico M. Stefanini

386-390

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Reply to: Bayesian Network Integrated Testing Strategy and beyond

Joanna Jaworska

391

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Corrections

Erratum to Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

Nina Hasiwa, Mardas Daneshian, Peter Bruegger, Stefan Fennrich, Astrid Hochadel, Sebastian Hoffmann, Felix E. Rivera-Mariani, Christoph Rockel, Stefanie Schindler, Ingo Spreitzer, Sandra Stoppelkamp, Kranthi Vysyaraju, Thomas Hartung

352

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Corners

392-400

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News

401-407

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Calendar

308

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Imprint

408

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Instructions to authors

292

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Cover

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