Editorial

Sonja von Aulock

U2

Mechanistic validation

Thomas Hartung, Sebastian Hoffmann, Martin Stephens

119-130

Uncertainty of testing methods – What do we (want to) know?

Martin Paparella, Mardas Daneshian, Romana Hornek-Gausterer, Maximilian Kinzl, Ilse Mauritz, Simone Mühlegger

131-144

A 155-plex high-throughput in vitro coregulator binding assay for (anti-)estrogenicity testing evaluated with 23 reference compounds

Si Wang, René Houtman, Diana Melchers, Jac Aarts, Ad Peijnenburg, Rinie van Beuningen, Ivonne Rietjens, Toine F. Bovee

145-157

Serum-reduced and serum-free media for differentiation of Caco-2 cells

Simonetta Ferruzza, Carlotta Rossi, Yula Sambuy, Maria Laura Scarino

159-168

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

Nina Hasiwa, Mardas Daneshian, Peter Bruegger, Stefan Fennrich, Astrid Hochadel, Sebastian Hoffmann, Felix E. Rivera-Mariani, Christoph Rockel, Stefanie Schindler, Ingo Spreitzer, Sandra Stoppelkamp, Kranthi Vysyaraju, Thomas Hartung

169-208

Metabolomics in toxicology and preclinical research

Tzutzuy Ramirez, Mardas Daneshian, Hennicke Kamp, Frederic Y. Bois, Malcolm R. Clench, Muireann Coen, Beth Donley, Steven M. Fischer, Drew R. Ekman, Eric Fabian, Claude Guillou, Joachim Heuer, Helena T. Hogberg, Harald Jungnickel, Hector C. Keun, Gerhard Krennrich, Eckart Krupp, Andreas Luch, Fozia Noor, Erik Peter, Bjoern Riefke, Mark Seymour, Nigel Skinner, Lena Smirnova, Elwin Verheij, Silvia Wagner, Thomas Hartung, Bennard van Ravenzwaay, Marcel Leist

209-225

Advanced tests for skin and respiratory sensitization assessment

Costanza Rovida, Stefan F. Martin, Manon Vivier, Hans Ulrich Weltzien, Erwin Roggen

231-252

Towards evidence-based translational research: The pros and cons of conducting systematic reviews of animal studies

Judith van Luijk, Marlies Leenaars, Carlijn Hooijmans, Kim Wever, Rob de Vries, Merel Ritskes-Hoitinga

256-257