Editorial

Sonja von Aulock

U2

Development, validation and testing of a human tissue engineered hypertrophic scar model

Leonarda J. van den Broek, Frank B. Niessen, Rik J. Scheper, Susan Gibbs

389-402

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

Bas J. Blaauboer, Kim Boekelheide, Harvey J. Clewell, Mardas Daneshian, Milou M. L. Dingemans, Alan M. Goldberg, Marjoke Heneweer, Joanna Jaworska, Nynke I. Kramer, Marcel Leist, Hasso Seibert, Emanuela Testai, Rob J. Vandebriel, James D. Yager, Joanne Zurlo

411-425

Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods

Marcel Leist, Brett A. Lidbury, Chihae Yang, Patrick J. Hayden, Jens M. Kelm, Stephanie Ringeissen, Ann Detroyer, Jean R. Meunier, James F. Rathman, George R. Jr. Jackson, Gina Stolper, Nina Hasiwa

373-388

The ox-foot-model for investigating endoluminal thermal treatment modalities of varicosis vein diseases

Ronald Sroka, Kathrin Weick, Stefanie Steckmaier, Bernd Steckmaier, Radka Blagova, Ina Sroka, Mojtaba Sadeghi-Azandaryani, Johann Maierl, Claus-Georg Schmedt

403-410

Practical aspects in the application of the new legislation: alternative methods and 3R principle, role of ethical committees and animal suffering

Francesca Caloni, Patrizia Costa, Gianni Dal Negro, Isabella De Angelis, Giovanna Lazzari, Giacomo Metteucci, Augusto Vitale

437-439

Outcomes of a Dutch workshop on improvements for the 3Rs in daily practice

Judith van Luijk, Marlies Leenaars, Anne Marie van Dongen, Lilian van der Vaart, Merel Ritskes-Hoitinga

440-443