Editorial

Sonja von Aulock

U2

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Food for Thought ...

Towards tailored assays for cell-based approaches to toxicity testing

Gian Paolo Rossini, Thomas Hartung

359-372

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Articles

Development, validation and testing of a human tissue engineered hypertrophic scar model

Leonarda J. van den Broek, Frank B. Niessen, Rik J. Scheper, Susan Gibbs

389-402

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The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

Bas J. Blaauboer, Kim Boekelheide, Harvey J. Clewell, Mardas Daneshian, Milou M. L. Dingemans, Alan M. Goldberg, Marjoke Heneweer, Joanna Jaworska, Nynke I. Kramer, Marcel Leist, Hasso Seibert, Emanuela Testai, Rob J. Vandebriel, James D. Yager, Joanne Zurlo

411-425

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Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods

Marcel Leist, Brett A. Lidbury, Chihae Yang, Patrick J. Hayden, Jens M. Kelm, Stephanie Ringeissen, Ann Detroyer, Jean R. Meunier, James F. Rathman, George R. Jr. Jackson, Gina Stolper, Nina Hasiwa

373-388

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The ox-foot-model for investigating endoluminal thermal treatment modalities of varicosis vein diseases

Ronald Sroka, Kathrin Weick, Stefanie Steckmaier, Bernd Steckmaier, Radka Blagova, Ina Sroka, Mojtaba Sadeghi-Azandaryani, Johann Maierl, Claus-Georg Schmedt

403-410

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Letters

Human AB serum as an alternative to fetal bovine serum for endothelial and cancer cell culture

David Cánovas, Nigel Bird

426-428

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Meeting Reports

Animal Law and Ethics: Reflecting on European, American, and Asian Concepts

Eveline Schneider Kayasseh

433-435

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17th European Congress on Alternatives to Animal Testing

Stefanie Schindler

436

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Practical aspects in the application of the new legislation: alternative methods and 3R principle, role of ethical committees and animal suffering

Francesca Caloni, Patrizia Costa, Gianni Dal Negro, Isabella De Angelis, Giovanna Lazzari, Giacomo Metteucci, Augusto Vitale

437-439

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Outcomes of a Dutch workshop on improvements for the 3Rs in daily practice

Judith van Luijk, Marlies Leenaars, Anne Marie van Dongen, Lilian van der Vaart, Merel Ritskes-Hoitinga

440-443

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Corrections

Erratum to Guidance on Determining Indispensability and Balancing Potential Benefits of Animal Experiments with Costs to the Animals with Specific Consideration of EU Directive 2010/63/EU

Toni Lindl, Ulrike Gross, Irmela Ruhdel, Sonja von Aulock, Manfred Völkel

429-432

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Corners

445-454

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News

455-466

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Calendar

467

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Imprint

468

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Instructions to authors

444

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Cover

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