Vol. 35 No. 1 (2018) | ALTEX - Alternatives to animal experimentation

Editorial

Sonja von Aulock

U2

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Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US

Thomas Hartung

3-25

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Prediction of acute inhalation toxicity using in vitro lung surfactant inhibition

Jorid B. Sørli, Yishi Huang, Emilie Da Silva, Jitka S. Hansen, Yi Y. Zuo, Marie Frederiksen, Asger W. Nørgaard, Niels E. Ebbehøj, Søren T. Larsen, Karin S. Hougaard

26-36

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A validated algorithm for selecting non-toxic chemical concentrations

Julita Stadnicka-Michalak, Melanie Knöbel, Anže Županič, Kristin Schirmer

37-50

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Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

Weihsueh A. Chiu, Kathryn Z. Guyton, Matthew T. Martin, David M. Reif, Ivan Rusyn

51-64

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Ex vivo model unravelling cell distribution effect in hydrogels for cartilage repair

Vivian H. M. Mouser, Noёl M. M. Dautzenberg, Riccardo Levato, Mattie H. P. van Rijen, Wouter J. A. Dhert, Jos Malda, Debby Gawlitta

65-76

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Extracorporeal perfusion of isolated organs of large animals – Bridging the gap between in vitro and in vivo studies

Carola R. Daniel, Raphael Labens, David Argyle, Theresia F. Licka

77-98

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Fetal bovine serum (FBS): Past – present – future

Jan van der Valk, Karen Bieback, Christiane Buta, Brett Cochrane, Wilhelm G. Dirks, Jianan Fu, James J. Hickman, Christiane Hohensee, Roman Kolar, Manfred Liebsch, Francesca Pistollato, Markus Schulz, Daniel Thieme, Tilo Weber, Joachim Wiest, Stefan Winkler, Gerhard Gstraunthaler

99-118

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Comment on “Alternative acute oral toxicity assessment under REACH based on sub-acute toxicity values”

Roland Buesen, Uwe Oberholz, Ursula G. Sauer, Robert Landsiedel

119-121

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Reply to Comment on “Alternative acute oral toxicity assessment under REACH based on sub-acute toxicity values”

Andrea Gissi, Kimmo Louekari, Laurence Hoffstadt, Norbert Bornatowicz, Alberto M. Aparicio

121-122

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1st INEXO Symposium: Alternative models in vitro, ex ovo and organisms: From research to applications in pathologies and aging

Philippe Nirdé, Myriam Richaud, Hinda Dabboue, Jean-Pierre Reynier, Simon Galas, Laure-Anaïs Vincent, Jean-Pierre Moles, Gilberte Marti-Mestres, Paul Chambon

123-125

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In silico methods – Computational alternatives to animal testing

Annemarie Lang, Andrea Volkamer, Laura Behm, Susanna Röblitz, Rainald Ehrig, Marlon Schneider, Liesbet Geris, Joerg Wichard, Frank Buttgereit

126-128

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Corners

Sonja von Aulock

129-136

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Imprint

Sonja von Aulock

U3

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Cover

Sonja von Aulock

pdf

Editorial

Editorial

Food for Thought ...

Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US

Articles

Prediction of acute inhalation toxicity using in vitro lung surfactant inhibition

A validated algorithm for selecting non-toxic chemical concentrations

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

Ex vivo model unravelling cell distribution effect in hydrogels for cartilage repair

Extracorporeal perfusion of isolated organs of large animals – Bridging the gap between in vitro and in vivo studies

Fetal bovine serum (FBS): Past – present – future

Comments

Comment on “Alternative acute oral toxicity assessment under REACH based on sub-acute toxicity values”

Reply to Comment on “Alternative acute oral toxicity assessment under REACH based on sub-acute toxicity values”

Meeting Reports

1st INEXO Symposium: Alternative models in vitro, ex ovo and organisms: From research to applications in pathologies and aging

In silico methods – Computational alternatives to animal testing

Corners

Corners

Imprint

Imprint

Cover

Cover