Editorial

Sonja von Aulock

U2

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Food for Thought ...

Sex and media: Considerations for cell culture studies

Roberta de Souza Santos, Aaron P. Frank, Biff F. Palmer, Deborah J. Clegg

435-440

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Articles

A human population-based organotypic in vitro model for cardiotoxicity screening

Fabian Grimm, Alexander Blanchette, John S. House, Kyle Ferguson, Nan-Hung Hsieh, Chimeddulam Dalaijamts, Alec A. Wright, Blake Anson, Fred A. Wright, Weihsueh A. Chiu, Ivan Rusyn

441-452

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Material-mediated pyrogens in medical devices: Applicability of the in vitro Monocyte Activation Test

Lindsey K. Borton, Kelly P. Coleman

453-463

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Completely defined co-culture of adipogenic differentiated ASCs and microvascular endothelial cells

Ann-Cathrin Volz, Larissa Hack, Franziska B. Atzinger, Petra J. Kluger

464-476

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Adaptation of the human Cell Line Activation Test (h-CLAT) to animal-product-free conditions

Alexander Edwards, Lottie Roscoe, Christopher Longmore, Fiona Bailey, Bushra Sim, Carol Treasure

477-488

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Replacement of foot-and-mouth disease virus cattle tongue titration by in vitro titration

Aldo Dekker, Froukje van Hemert-Kluitenberg, Anna H. Oosterbaan, Kimberly Moonen, Laure Mouton

489-494

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Testing vaginal irritation with the Hen’s Egg Test-Chorioallantoic Membrane assay

Rita Palmeira-de-Oliveira, Rita Monteiro Machado, José Martinez-de-Oliveira, Ana Palmeira-de-Oliveira

495-503

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Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system

Brian D. Chapron, Alenka Chapron, Brian Phillips, Miracle C. Okoli, Danny D. Shen, Edward J. Kelly, Jonathan Himmelfarb, Kenneth E. Thummel

504-515

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Letters

Lowering the p-value from 0.05 to 0.005 conflicts with the 3R rules – an advocacy for alternatives to hypothesis testing with the p-value approach

Konradin Metze, Fernanda Aparecida Borges da Silva, Irene Lorand-Metze

516-517

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The ethical evaluation of animal experiments deserves more than empty phrases

Tilo Weber

518-519

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Meeting Reports

3Replacement Winter School – Out of the barriers: In vitro models in toxicology

Francesca Caloni, Yula Sambuy, Guerino Lombardi, Silvia Dotti, Isabella De Angelis

520-521

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Corners

522-526

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Editorial material

ALTEX Edition membership application

527

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Imprint

528

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TIERethik

U3

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Cover

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