The transatlantic think tank for toxicology is a collaboration of the toxicologically oriented chairs in Baltimore, Konstanz and Utrecht sponsored by the Doerenkamp Zbinden Foundation.

2024

Golden, E., Allen, D., Amberg, A., Anger, L. T., Baker, E., Baran, S. W., Bringezu, F., Clark, M., Duchateau-Nguyen, G., Escher, S. E., Giri, V., Grevot, A., Hartung, T., Li, D., Lotfi, L., Muster, W., Snyder, K., Wange, R., & Steger-Hartmann, T. (2024). Toward implementing virtual control groups in nonclinical safety studies: Workshop report and roadmap to implementation. ALTEX 41, 282–301. doi:10.14573/altex.2310041

Maertens, A., Antignac, E., Benfenati, E., Bloch, D., Fritsche, E., Hoffmann, S., Jaworska, J., Loizou, G., McNally, K., Piechota, P., Roggen, E. L., Teunis, M., & Hartung, T. (2024). The probable future of toxicology - probabilistic risk assessment. ALTEX 41, 273–281. doi:10.14573/altex.2310301

2023

Knight, J., Hartung, T. and Rovida, C. (2023). 4.2 million and counting… The animal toll for REACH systemic toxicity studies. ALTEX 40, 389–407. doi:10.14573/altex.2303201

2022

Krewski, D., Saunders-Hastings, P., Baan, R. A., Barton-Maclaren, T. S., Browne, P., Chiu, W. A., Gwinn, M., Hartung, T., Kraft, A. D., Lam, J., Lewis, R. J., Sanaa, M., Morgan, R. L., Paoli, G., Rhomberg, L., Rooney, A., Sand, S., Schünemann, H. J., Straif, K., Thayer, K. A., & Tsaioun, K. (2022). Development of an evidence-based risk assessment framework. ALTEX 39, 667–693. doi:10.14573/altex.2004041

Cassotta, M. ., Geerts, H. ., Harbom, L., Outeiro, T. F., Pediaditakis, I., Reiner, O., Schildknecht, S., Schwamborn, J. C., Bailey, J., Herrmann, K., & Hogberg, H. T. (2022). The future of Parkinson’s disease research: A new paradigm of human specific investigation is necessary… and possible. ALTEX 39, 694–709. doi:10.14573/altex.2203161

Hoffmann, S., Aiassa, E., Angrish, M., Beausoleil, . C. ., Bois, F. Y. ., Ciccolallo, L., Craig, P. S., de Vries, R. B. M. ., Dorne, J. L. C. M. ., Druwe, I. L., Edwards, S. W. ., Eskes, C., Georgiadis, M., Hartung, T. ., Kienzler, A., Kristjansson, E. A. ., Lam, J. ., Martino, L., Meek, B., Morgan, R. L. ., Munoz-Guajardo, I., Noyes, P. D. ., Parmelli, E. ., Piersma, A., Rooney, A., Sena, E., Sullivan, K., Tarazona, J., Terron, A., Thayer, K., Turner, J., Verbeek, J., Verloo, D., Vinken, M., Watford, S., Whaley, P., Wikoff, D., Willett, K., & Tsaioun, K. (2022). Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. ALTEX 39, 499–518. doi:10.14573/altex.2202141

2021

Knight, J., Rovida, C., Kreiling, R. et al. (2021). Continuing animal tests on cosmetic ingredients for REACH in the EU. ALTEX 38, 653-668. doi:10.14573/altex.2104221

Whaley, P., Blaauboer, B. J., Brozek, J. et al. (2021). Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do. ALTEX 38, 513-522. doi:10.14573/altex.2106111

 

2020

Rovida, C., Barton-Maclaren, T., Benfenati, E. et al. (2020). Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology. ALTEX 37, 579-606. doi:10.14573/altex.191218

Marx, U., Akabane, T., Andersson, T. et al. (2020). Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development, ALTEX 37, 365-394. doi:10.14573/altex.2001241

 

2019

Beilmann, M., Boonen, H., Czich, A. et al. (2019). Optimizing drug discovery by investigative toxicology: Current and future trends. ALTEX 36, 289-313. doi:10.14573/altex.1808181

 

2018

Pamies, P., Bal-Price, A., Chesne, C. et al. (2018). Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems. ALTEX 35, 353-378. doi:10.14573/altex.1710081

Bal-Price A., Hogberg, H. T., Crofton. K. M. et al. (2018). Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX 35, 306-352. doi:10.14573/altex.1712081

 

2017

Kerecman Myers, D., Goldberg, A. M., Poth, A. et al. (2017). From in vivo to in vitro: The medical device testing paradigm shift. ALTEX 34, 479-500. doi:10.14573/altex.1608081

Pamies, D., Bal-Price, A., Simeonov, A. et al. (2017). Good cell culture practice for stem cells and stem-cell-derived models. ALTEX 34, 95-132. doi:10.14573/altex.1607121

Aschner, M., Ceccatelli, S., Daneshian, M. et al. (2017). Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists and criteria for their selection and use. ALTEX 34, 49-74. doi:10.14573/altex.1604201

 

2016

Marx, U., Andersson, T. B., Bahinski, A. et al. (2016). Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX 33, 272-321. doi:10.14573/altex.1603161

Zhu, H., Bouhifd, M., Donley, E. et al. (2016). Supporting read-across using biological data. ALTEX 33, 167-182. doi:10.14573/altex.1601252

Ball, N., Cronin, M. T., Shen, J. et al. (2016). Toward good read-across practice (GRAP) guidance. ALTEX 33, 149-166. doi:10.14573/altex.1601251

 

2015

Gordon, S., Daneshian, M., Bouwstra, J. et al. (2015). Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. ALTEX 32, 327-378. doi:10.14573/altex.1510051

Bouhifd, M., Beger, R., Flynn, T. et al. (2015). Quality assurance of metabolomics. ALTEX 32, 319-326. doi:10.14573/altex.1509161

Rovida, C., Alepee, N., Api, A. M. et al. (2015). Integrated testing strategies (ITS) for safety assessment. ALTEX 32, 25-40. doi:10.14573/altex.1411011

 

2014

van Vliet, E., Daneshian, M., Beilmann, M. et al. (2014). Current approaches and future role of high content imaging in safety sciences and drug discovery. ALTEX 31, 479-493. doi:10.14573/altex.1405271

Alepee, N., Bahinski, A., Daneshian, M. et al. (2014). State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX 31, 441-477. doi:10.14573/altex1406111

Leist, M., Hasiwa, N., Rovida, C. et al. (2014). Consensus report on the future of animal-free systemic toxicity testing. ALTEX 31, 341-356. doi:10.14573/altex.1406091

Ferrario, D., Brustio, R. and Hartung, T. (2014). Glossary of reference terms for alternative test methods and their validation. ALTEX 31, 319-335. doi:10.14573/altex.1403311

Juberg, D. R., Borghoff, S. J., Becker, R. A. et al. (2014). Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. ALTEX 31, 63-78. doi:10.14573/altex.1309171

Kleensang, A., Maertens, A., Rosenberg, M. et al. (2014). Pathways of toxicity. ALTEX 31, 53-61. doi:10.14573/altex.1309261

 

2013

Daneshian, M., Botana, L. M., Dechraoui Bottein, M. Y. et al. (2013). A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems. ALTEX 30, 487-545. doi:10.14573/altex.2013.4.487

Parks Saldutti, L., Beyer, B. K., Breslin, W. et al. (2013). In vitro testicular toxicity models: Opportunities for advancement via biomedical engineering techniques. ALTEX 30, 353-377. doi:10.14573/altex.2013.3.353

Ramirez, T., Daneshian, M., Kamp, H. et al. (2013). Metabolomics in toxicology and preclinical research. ALTEX 30, 209-225. doi:10.14573/altex.2013.2.209

Hasiwa, N., Daneshian, M., Bruegger, P. et al. (2013). Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test. ALTEX 30, 169-208. doi:10.14573/altex.2013.2.169.
Erratum ALTEX 30, 352. http://www.altex.ch/resources/raltex_2013_3_352_352_Erratum2.pdf
Addendum ALTEX 31, 226. http://www.altex.ch/resources/altex_2014_2_226__Addendum11.pdf

 

2012

Blaauboer, B. J., Boekelheide, K., Clewell, H. J. et al. (2012). The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. ALTEX 29, 411-425. doi:10.14573/altex.2012.4.411

Ferrario, D. and Rabbit, R. R. (2012). Analysis of the proposed EU regulation concerning biocide products and its opportunities for alternative approaches and a toxicology for the 21^st century. ALTEX 29, 157-172. doi:10.14573/altex.2012.2.157

Basketter, D. A., Clewell, H., Kimber, I. et al. (2012). A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing. ALTEX 29, 3-91. doi:10.14573/altex.2012.1.003

 

2011

Zurlo, J., Bayne, K. A., Brown, D. C. et al. (2011). Critical evaluation of the use of dogs in biomedical research and testing. ALTEX 28, 355-359. doi:10.14573/altex.2011.4.355

Daneshian, M., Akbarsha, M. A., Blaauboer, B. et al. (2011). A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation. ALTEX 28, 341-352. doi:10.14573/altex.2011.4.341

Hasiwa, N., Bailey, J., Clausing, P. et al. (2011). Critical evaluation of the use of dogs in biomedical research and testing in Europe. ALTEX 28, 326-340. doi:10.14573/altex.2011.4.326

Rovida, C., Longo, F. and Rabbit, R. R. (2011). How are reproductive toxicity and developmental toxicity addressed in REACH dossiers? ALTEX 28, 273-294. doi:10.14573/altex.2011.4.273

Silbergeld, E. K., Contreras, E. Q., Hartung, T. et al. (2011). Nanotoxicology: “The end of the beginning” – Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. ALTEX 28, 236-241. doi:10.14573/altex.2011.3.236

Hartung, T., Blaauboer, B. J., Bosgra, S. et al. (2011). An expert consortium review of the EC-commissioned report “Alternative (non-animal) methods for cosmetics testing: Current status and future prospects – 2010”. ALTEX 28, 183-209. doi:10.14573/altex.2011.3.183

 

2010

Hartung, T. (2010). Comparative analysis of the revised Directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC. ALTEX 27, 285-303. doi:10.14573/altex.2010.4.285

Kuegler, P. B., Zimmer, B., Waldmann, T. et al. (2010). Markers of murine embryonic and neural stem cells, neurons and astrocytes: Reference points for developmental neurotoxicity testing. ALTEX 27, 17-42. doi:10.14573/altex.2010.1.16

 

2009

Rovida, C. and Hartung, T. (2009). Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals. ALTEX 26, 187-208. doi:10.14573/altex.2009.3.187

 

2008

Leist, M., Bremer, S., Brundin, P. et al. (2008). The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. ALTEX 25, 163-190. doi:10.14573/altex.2008.3.163