On March 11, the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods released an update of the Integrated Chemical Environment (ICE). ICE provides data and tools to help develop, assess, and interpret chemical safety tests. The update introduces a new user interface to simplify searches and new tools that will let users explore chemical properties and toxicity in more detail.
The ICE 3.0 update features improvements to the in vitro to in vivo extrapolation (IVIVE) tool. In response to customer requests, ICE now allows users to upload their own data for IVIVE analyses. A new physiologically based toxicokinetic model has been added, and the output graphics have been improved.
Other new resources in ICE 3.0 include:
- User interface improvements
- Organization of Tox21 assays in query setup menus based on modes of action
- Availability of data from in vitro dermal irritation assays
- Updated property predictions for over 800,000 chemicals from OPERA (Open Structure-activity/property Relationship App; https://ntp.niehs.nih.gov/go/opera)
- Mapping of Tox21 assays to controlled terms from the NCI Metathesaurus
ICE is available at https://ice.ntp.niehs.nih.gov/.