Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Investigation of the publication rate of recent research projects using non-human primates in France

Roland Cash, Lilas Courtot
Published: Jun 23, 2025
accepted manuscript sup1 sup2 sup3

Estimation of bioavailable concentration of endogenously formed N-nitrosamines by physiologically based kinetic modelling

Max Spaenig, Matthias Vogel, Tanja Hansen, Leroy Elenschneider, Anke Londenberg, Rhys Whomsley, Uwe Deppenmeier, Sylvia E. Escher
Published: Jun 23, 2025
accepted manuscript sup

Evaluation of a high-throughput in-vitro-to-in-vivo extrapolation (IVIVE) workflow for the prioritization of potential developmental toxicity of chemicals

Matthew W. Linakis, Rebecca A. Clewell, Jerry Campbell, P. Robinan Gentry, Harvey J. 3rd Clewell
Published: May 28, 2025
accepted manuscript sup1 sup2

From cellular perturbation to probabilistic risk assessments

Alexandra Maertens, Breanne Kincaid, Eric Bridgeford, Celine Brochot, Arthur de Carvalho e Silva, Jean-Lou C. M. Dorne, Liesbet Geris, Trine Husøy, Nicole Kleinstreuer, Luiz C. M. Ladeira, Alistair Middleton, Joe Reynolds, Blanca Rodriguez, Erwin L. Roggen, Giulia Russo, Kris Thayer, Thomas Hartung
Published: May 26, 2025
accepted manuscript

Determination of U-SENS™ borderline range thresholds to address uncertainty for skin sensitization assessment in a regulatory context

Laurent Nardelli, Fleur Tourneix, Leopold Carron, Erwin van Vliet, Nathalie Alépée
Published: May 23, 2025
accepted manuscript sup1 sup2

KoCVAM-led validation of KeraSkin™ Phototoxicity Assay for inclusion in OECD TG 498

Nam-Hee Kang, Chang-Eon Park, So-Hee Kim, Eunji Gwak, Seongsook Kim, Min-Gyu Go, Joohwan Kim, Sun-Wook Woo
Published: May 23, 2025
accepted manuscript sup

Making safety decisions for a sunscreen active ingredient using next-generation risk assessment: Benzophenone-4 case study

Maria T. Baltazar, Sophie Cable, Richard Cubberley, Nicola J. Hewitt, Jade Houghton, Predrag Kukic, Hequn Li, Sophie Malcomber, Beate Nicol, Ruth Pendlington, Ans Punt, Joe Reynolds, Sharon Scott, Sandrine Spriggs, Matthew P. Dent
Published: May 19, 2025
accepted manuscript sup1 sup2

Validation of an Endopep-suspension immunoassay for the diagnostics of human botulism

Maximilian Steinberg, Laura-Varenne Wilk, Daniel Stern, Jasmin Weisemann, Ute Messelhäußer, Matthias Wittwer, Maren Krüger, Hans Werner Mages, Andreas Rummel, Martin B. Dorner, Brigitte G. Dorner
Published: May 19, 2025
accepted manuscript sup

Moving towards making (quantitative) structure-activity relationships ((Q)SARs) for toxicity-related endpoints findable, accessible, interoperable and reusable (FAIR)

Samuel J. Belfield, Homa Basiri, Swapnil Chavan, Georgios Chrysochoou, Steven J. Enoch, James W. Firman, Anish Gomatam, Barry Hardy, Palle S. Helmke, Judith C. Madden, Uko Maran, Eric March-Vila, Nikolai G. Nikolov, Manuel Pastor, Geven Piir, Sulev Sild, Aljoša Smajić, Nicoleta Spînu, Eva B. Wedebye, Mark T. D. Cronin
Published: May 19, 2025
accepted manuscript

Exploring the synergy of CRISPR and microphysiological systems

Emanuele Celauro, Amer F. Saleh, Prathap Kumar Mahalingaiah, Lisa Mohamet, Rhiannon David, Roberto Nitsch
Published: May 9, 2025
accepted manuscript

The turning point: April 2025 marks historic shift in US animal testing policy

Thomas Hartung
Published: Apr 30, 2025
accepted manuscript

Virtual control groups in non-clinical toxicology – A replicability challenge

Thomas Steger-Hartmann, Guillemette Duchateau-Nguyen, Frank Bringezu, Manuela Onidi, Martina Stirn
Published: Apr 29, 2025
accepted manuscript

Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using Caenorhabditis elegans

Javier Huayta, Sarah Seay, Joseph 3rd Laster, Nelson A. Jr Rivera, Abigail S. Joyce, P. Lee Ferguson, Heileen Hsu-Kim, Joel N. Meyer
Published: Apr 23, 2025
accepted manuscript sup

Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development

Patrick J. Devine, Manti Guha, Jason E. Ekert, Anna K. Kopec, James R. Gosset, May S. Freag, Matthew P. Wagoner, Philip Hewitt, Kate Harris, Myriam Lemmens, Nakissa Sadrieh, Donna Mendrick, David M. Stresser, Leslie Valencia, Paul C. Brown, Ronald L. Wange, Amy Avila, Kevin Ford, Robert Geiger, Martha Garcia, Jessica A. Bonzo, John P. Gleeson, Christine C. Orozco, Qun Li, Chris Hinckley, Reiner Class, Josephine M. McAuliffe, Amy Tran-Guzman, Francesco Nevelli, Gonçalo Gamboa da Costa, Dayton Petibone, Tomomi Kiyota, Qiang Shi, Rhiannon N. Hardwick
Published: Apr 11, 2025
accepted manuscript

Animal pilot studies should not be used to estimate sample size if effect size and population variance are unknown

Alexander D. Bird, Peter Jedlicka, Jochen Wilhelm
Published: Apr 9, 2025
accepted manuscript

The effect of surfactants and film-forming polymers on pulmonary surfactant function measured in vitro is dose rate-dependent

Sreyoshee Roy Sengupta, Hugh Barlow, Maria T. Baltazar, Jorid B. Sørli
Published: Apr 7, 2025
accepted manuscript sup

Organizing shipping studies to evaluate the transferability of cell- and tissue-based test systems and reagents: An end user perspective

Hans Raabe, Anna van der Zalm, Amy Clippinger, Gertrude-Emilia Costin
Published: Mar 27, 2025
accepted manuscript

EU roadmap for phasing out animal testing for chemical safety assessments: Recommendations from a multi-stakeholder roundtable

Laurence Walder, Giorgia Pallocca, Luísa F. Bastos, Manon Beekhuijzen, Francois Busquet, Helder Constantino, Marco Corvaro, Lilas Courtot, Beate Escher, Rebeca Fernandez, Emeline Gougeon, Love Hansell, Matthias Herzler, Laura Holden, Romana Hornek-Gausterer, Amaia Irizar, Helena Kandarova, Petra Kern, Susanne Kolle, Katia Lacasse, Isabelle Lee, Donna S. Macmillan, Gavin Maxwell, Orla Moriarty, Stephanie Nadzialek, Julia Pochat, Kirsty Reid, Marion Revel, Merel Ritskes-Hoitinga, Tomasz Sobanski, Gilly Stoddart, Dylan Underhill, Mandy Veillette, Jelle Vriend, Carl Westmoreland, Julia Baines
Published: Mar 26, 2025
accepted manuscript

Statistical derivation of cut-off values for in vitro assays

Christian Tobias Willenbockel, Mercedes Diez-Cocero, Denise Bloch
Published: Mar 18, 2025
accepted manuscript sup

Improved identification of human hepatotoxic potential by summary variables of gene expression

Wiebke Albrecht, Tim Brecklinghaus, Marieke Stolte, Franziska Kappenberg, Lisa Gründler, Peng Chen, Cristina Cadenas, Georg Damm, Karolina Edlund, Ahmed Ghallab, Rosemarie Marchan, Patrick Nell, Jörg Reinders, Daniel Seehofer, Anne-Cathrin Behr, Albert Braeuning, Christoph van Thriel, Iain Gardner, Jörg Rahnenführer, Jan G. Hengstler
Published: Feb 14, 2025
accepted manuscript sup

Potential value of animal microphysiological systems

Paul C. Brown, Barry H. Hooberman, Brianna L. Skinner, Claudia Wrzesinski, Dayton M. Petibone, Kevin A. Ford, Kristi Muldoon-Jacobs, Kyung E. Sung, Luis G. Jr. Valerio, Nakissa N. Sadrieh, Paul C. Howard, Peter L. Goering, Shelby A. Skoog, Suzanne C. Fitzpatrick, Tracy Chen, Tracy C. MacGill, Donna L. Mendrick
Published: Aug 7, 2024
accepted manuscript