Latest Articles | ALTEX - Alternatives to animal experimentation

Comparison of pyrogen assays by testing products exhibiting low endotoxin recovery

Tammy Thurman, Carol J. Lahti, Jeanne M. Mateffy, Ren-Yo Forng, Friedrich von Wintzingerode, Lindsey M. Silva, Sven M. Deutschmann, Ned Mozier

DOI: https://doi.org/10.14573/altex.2202021

Published: Jun 24, 2022

accepted manuscript sup

Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity

Nancy C. Baker, Jocylin D. Pierro, Laura W. Taylor, Thomas B. Knudsen

DOI: https://doi.org/10.14573/altex.2202231

Published: Jun 23, 2022

accepted manuscript sup

How to formulate hypotheses and IATA to support grouping and read-across of nanoforms

Fiona Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristo, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone

DOI: https://doi.org/10.14573/altex.2203241

Published: Jun 22, 2022

accepted manuscript sup

A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level

Diana Karwelat, Julia Kühnlenz, Thomas Steger-Hartmann, Remi Bars, Helen Tinwell, Uwe Marx, Sophie Bauer, Oliver Born, Marian Raschke

DOI: https://doi.org/10.14573/altex.2108262

Published: Jun 21, 2022

accepted manuscript sup

Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation

Cormac Murphy, Elisabeth Naderlinger, Amber Mater, Roelof J. C. Kluin, Anja Wilmes

DOI: https://doi.org/10.14573/altex.2112204

Published: Jun 20, 2022

accepted manuscript sup1 sup2

Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing

Mark C. Daley, Ulrike Mende, Bum-Rak Choi, Patrick D. McMullen, Kareen L. K. Coulombe

DOI: https://doi.org/10.14573/altex.2109131

Published: Jun 1, 2022

accepted manuscript

Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment

Alex N. Cayley, Robert S. Foster, Emma Hill, Steven Kane, Grace Kocks, Alun Myden, Daniel Newman, Susanne A. Stalford, Jonathan D. Vessey, Reza Zarei, Antonio Anax F. de Oliveira

DOI: https://doi.org/10.14573/altex.2201311

Published: May 13, 2022

accepted manuscript

A microfluidic thyroid-liver platform to assess chemical safety in humans

Julia Kühnlenz, Diana Karwelat, Thomas Steger-Hartmann, Marian Raschke, Sophie Bauer, Özlem Vural, Uwe Marx, Helen Tinwell, Remi Bars

DOI: https://doi.org/10.14573/altex.2108261

Published: May 9, 2022

accepted manuscript sup

Dog as the experimental model: Laboratory uses of dogs in the United States

Sherry L. Ward, Pamela Osenkowski

DOI: https://doi.org/10.14573/altex.2109101

Published: Apr 21, 2022

accepted manuscript sup

Exploration of the GARDskin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs

Andy Forreryd, Robin Gradin, Charles Humfrey, Len Sweet, Henrik Johansson

DOI: https://doi.org/10.14573/altex.2201281

Published: Apr 21, 2022

accepted manuscript

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

Qin Wang, Jennifer D. Cohen, Tomoya Yukawa, Heather Estrella, Chris Leonard, Jairo Nunes, Colin Choi, Lauren Lewis, Kevin S. Baker, Kazuhiro Kuga, Yvonne P. Dragan, Matthew P. Wagoner, Nibha Mishra

DOI: https://doi.org/10.14573/altex.2112221

Published: Apr 19, 2022

accepted manuscript sup1 sup2 sup3 (video)

Validation of the monocyte activation test with three therapeutic monoclonal antibodies

Ruth Daniels, Wim Van der Elst, Nele Dieltjens, Tinne Appels, Chi K. So, Thomas Nys, Liesbeth Voeten, Philip Breugelmans, Marijke W. A. Molenaar-de Backer, Eelo Gitz, Stephen Poole, Mehul Patel

DOI: https://doi.org/10.14573/altex.2111301

Published: Apr 14, 2022

accepted manuscript sup

Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach

Andreas Natsch, G. Frank Gerberick

DOI: https://doi.org/10.14573/altex.2201142

Published: Apr 11, 2022

accepted manuscript ESM1 ESM2 ESM3 ESM4

Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment

Andreas Natsch, G. Frank Gerberick

DOI: https://doi.org/10.14573/altex.2201141

Published: Apr 11, 2022

accepted manuscript ESM1 ESM2 ESM3 ESM4

The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible

Manuela Cassotta, Hugo Geerts, Lise Harbom, Tiago F. Outeiro, Iosif Pediaditakis, Orly Reiner, Stefan Schildknecht, Jens C. Schwamborn, Jarrod Bailey, Kathrin Herrmann, Helena T. Hogberg

DOI: https://doi.org/10.14573/altex.2203161

Published: Apr 8, 2022

accepted manuscript

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Giorgia Pallocca, Martijn J. Moné, Hennicke Kamp, Mirjam Luijten, Bob van de Water, Marcel Leist

DOI: https://doi.org/10.14573/altex.2204051

Published: Apr 7, 2022

accepted manuscript

The use of categorical regression in evidence integration

Patrick J. Farrell, Peter Aggett, Brittany Milton, Siva Ramoju, Don Mattison, Nicholas Birkett, Daniel Krewski

DOI: https://doi.org/10.14573/altex.2012022

Published: Mar 30, 2022

accepted manuscript sup

Open-source human skin model with an in vivo-like barrier for drug testing

Patrícia Zoio, Sara Lopes-Ventura, Joana Marto, Abel Oliva

DOI: https://doi.org/10.14573/altex.2111182

Published: Mar 23, 2022

accepted manuscript sup

Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform

Ji-Eun Seo, Xiaobo He, Levan Muskhelishvili, Pritpal Malhi, Nan Mei, Mugimane Manjanatha, Matthew Bryant, Tong Zhou, Timothy Robison, Xiaoqing Guo

DOI: https://doi.org/10.14573/altex.2201121

Published: Mar 18, 2022

accepted manuscript sup

Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays

John S. House, Fabian A. Grimm, William D. Klaren, Abigail Dalzell, Srikeerthana Kuchi, Shu-Dong Zhang, Klaus Lenz, Peter J. Boogaard, Hans B. Ketelslegers, Timothy W. Gant, Ivan Rusyn, Fred A. Wright

DOI: https://doi.org/10.14573/altex.2107051

Published: Mar 10, 2022

accepted manuscript sup

A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening

Arijit Bhattacharjee, Dhirendra Katti

DOI: https://doi.org/10.14573/altex.2107071

Published: Mar 7, 2022

accepted manuscript sup

Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks

Sebastian Hoffmann, Elisa Aiassa, Michelle Angrish, Claire Beausoleil, Frederic Y. Bois, Laura Ciccolallo, Peter S. Craig, Rob B. M. de Vries, Jean Lou C. M. Dorne, Ingrid L. Druwe, Stephen W. Edwards, Chantra Eskes, Marios Georgiadis, Thomas Hartung, Aude Kienzler, Elisabeth A. Kristjansson, Juleen Lam, Laura Martino, Bette Meek, Rebecca L. Morgan, Irene Munoz-Guajardo, Pamela D. Noyes, Elena Parmelli, Aldert Piersma, Andrew Rooney, Emily Sena, Kristie Sullivan, José Tarazona, Andrea Terron, Kris Thayer, Jan Turner, Jos Verbeek, Didier Verloo, Mathieu Vinken, Sean Watford, Paul Whaley, Daniele Wikoff, Kate Willett, Katya Tsaioun

DOI: https://doi.org/10.14573/altex.2202141

Published: Mar 1, 2022

accepted manuscript

A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells

Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa, Takayuki Yoshimoto

DOI: https://doi.org/10.14573/altex.2111181

Published: Feb 24, 2022

accepted manuscript sup

Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays

Rebecca von Hellfeld, Viktoriia Ovcharova, Samantha Bevan, Maria-Agapi Lazaridi, Caroline Bauch, Paul Walker, Susanne Hougaard Bennekou, Anna Forsby, Thomas Braunbeck

DOI: https://doi.org/10.14573/altex.2111021

Published: Feb 23, 2022

accepted manuscript sup1 sup2