Latest Articles | ALTEX - Alternatives to animal experimentation

Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment

Jan Turner, Pandora Pound, Carla Owen, Isobel Hutchinson, Marina Hop, David Y. S. Chau, Lady V. Barrios Silva, Mike Coleman, Audrey Dubourg, Lorna W. Harries, Victoria Hutter, J- Gerry Kenna, Volker M. Lauschke, Winfried Neuhaus, Clive Roper, Paul B. Watkins, Jonathan Welch, Laura R: Alvarez, Katy Taylor

DOI: https://doi.org/10.14573/altex.2212081

Published: Jan 18, 2023

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Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Martin Paparella

DOI: https://doi.org/10.14573/altex.2301121

Published: Jan 13, 2023

accepted manuscript

Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges

Onyi Irrechukwu, Ronnie Yeager, Rhiannon David, Jason Ekert, Anitha Saravanakumar, Colin K. Choi

DOI: https://doi.org/10.14573/altex.2204071

Published: Jan 12, 2023

accepted manuscript

Microphysiological endothelial models to characterize subcutaneous drug absorption

Giovanni S. Offeddu, Jean Carlos Serrano, Zhengpeng Wan, Mark A. Bryniarski, Sara C. Humphreys, Sophia W. Chen, Hamsini Dhoolypala, Kip Conner, Roger D. Kamm

DOI: https://doi.org/10.14573/altex.2207131

Published: Dec 15, 2022

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Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens

Sylvia E. Escher, Susan P. Felter, Heli Hollnagel, Alan R. Boobis, Chihae Yang, James Rathman, Mark T. D. Cronin, Monika Batke

DOI: https://doi.org/10.14573/altex.2210111

Published: Nov 11, 2022

accepted manuscript

Report on 2021 International Workshop for Non-animal Approaches in the Food Sector (Japan): Current status and avenues for further research

Satoshi Ohta, Shigeki Kimura, Daisuke Maejima, Kazutoshi Saito, Yasuhiro Tanaka, Satoshi Kojima, Tomohiro Kawaguchi, Takuya Kikuchi, Takuya Seki, Hsuan Chung, Risa Funaki, Tetsuya Kuhara, Hisako Hori, Yuichi Ito

DOI: https://doi.org/10.14573/altex.2209262

Published: Nov 10, 2022

accepted manuscript

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells

Anouck Thienpont, Stefaan Verhulst, Leo A. van Grunsven, Vera Rogiers, Tamara Vanhaecke, Birgit Mertens

DOI: https://doi.org/10.14573/altex.2206201

Published: Nov 4, 2022

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Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion

Pedro Caetano-Pinto, Pär Nordell, Tom Nieskens, Katie Haughan, Katherine S. Fenner, Simone H. Stahl

DOI: https://doi.org/10.14573/altex.2204011

Published: Nov 3, 2022

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The GARD™skin assay: Investigation of the applicability domain for metals

Andy Forreryd, Robin Gradin, Olivia Larne, Nissanka Rajapakse, Eliot Deag, Henrik Johansson

DOI: https://doi.org/10.14573/altex.2203021

Published: Nov 3, 2022

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Proceedings of a workshop to address animal methods bias in scientific publishing

Catharine E. Krebs, Celean Camp, Helder Constantino, Lilas Courtot, Owen Kavanagh, Sofia Batista Leite, Judith Madden, Alicia Paini, Brinda Poojary, Ignacio J. Tripodi, Emily R. Trunnell

DOI: https://doi.org/10.14573/altex.2210211

Published: Oct 31, 2022

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Comparison of piecewise structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network

Yang Cao, S. Jannicke Moe, Riccardo de Bin, Knut Erik Tollefsen, You Song

DOI: https://doi.org/10.14573/altex.2207113

Published: Oct 12, 2022

accepted manuscript

Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells

Keith A. Houck, Katie Paul Friedman, Madison Feshuk, Grace Patlewicz, Marci Smeltz, M. Scott Clifton, Barbara A. Wetmore, Sharlene Velichko, Antal Berenyi, Ellen L. Berg

DOI: https://doi.org/10.14573/altex.2203041

Published: Sep 15, 2022

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Application of immunocompetent microphysiological systems in drug development: Current perspective and recommendations

Xiaoting Wang, Anna K. Kopec, Mark Collinge, Rhiannon David, Christian Grant, Rhiannon N. Hardwick, Aaron Navratil, Nirav Patel, Wendy Rowan, Nikki Marshall

DOI: https://doi.org/10.14573/altex.2205311

Published: Aug 29, 2022

accepted manuscript

Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations

Ans Punt, Peter Bos, Betty Hakkert, Jochem Louisse

DOI: https://doi.org/10.14573/altex.2202131

Published: Jul 25, 2022

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Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity

Nancy C. Baker, Jocylin D. Pierro, Laura W. Taylor, Thomas B. Knudsen

DOI: https://doi.org/10.14573/altex.2202231

Published: Jun 23, 2022

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A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells

Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa, Takayuki Yoshimoto

DOI: https://doi.org/10.14573/altex.2111181

Published: Feb 24, 2022

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