Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Innovative in vitro method to study ventilator induced lung injury

Jon P. Joelsson, Iwona T. Myszor, Ari J. Arason, Saevar Ingthorsson, Paulina Cherek, Gabriel S. Windels, Kristjan Leosson, Gudmundur H. Gudmundsson, Thorarinn Gudjonsson, Sigurbergur Karason

DOI: https://doi.org/10.14573/altex.1901182

Published: Jun 5, 2019

Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model

Stefania Serra, Monica Vaccari, Maria Grazia Mascolo, Francesca Rotondo, Cristina Zanzi, Laura Polacchini, Christine Behle Wagner, Thorsten Kunkelmann, Sabine Perschbacher, Albrecht Poth, Sandro Grilli, Miriam N. Jacobs, Annamaria Colacci

DOI: https://doi.org/10.14573/altex.1812173

Published: Jun 3, 2019

The HaCaT/THP-1 Cocultured Activation Test (COCAT) for skin sensitization: a study of intra-lab reproducibility and predictivity

Chantra Eskes, Jennifer Hennen, Mario Schellenberger, Sebastian Hoffmann, Sabine Frey, Daniela Goldinger-Oggier, Niklas Peter, Erwin van Vliet, Brunhilde Blömeke

DOI: https://doi.org/10.14573/altex.1905031

Published: May 27, 2019

Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing

James C. Y. Chan, Shawn P. F. Tan, Zee Upton, Eric C. Y. Chan

DOI: https://doi.org/10.14573/altex.1812051

Published: May 10, 2019

Assessment of iron oxide nanoparticle ecotoxicity on regeneration and homeostasis in the replacement model system Schmidtea mediterranea

Thao A. Tran, Michelle Hesler, Oscar H. Moriones, Alba Jimeno-Romero, Benjamin Fischer, Neus G. Bastús, Victor Puntes, Sylvia Wagner, Yvonne L. Kohl, Luca Gentile

DOI: https://doi.org/10.14573/altex.1902061

Published: Apr 26, 2019

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition

Jie Mei, Stefanie Banneke, Janet Lips, Melanie T. C. Kuffner, Christian J. Hoffmann, Ulrich Dirnagl, Matthias Endres, Christoph Harms, Julius V. Emmrich

DOI: https://doi.org/10.14573/altex.1812231

Published: Apr 18, 2019

Activation of TRPA1 by volatile organic chemicals leading to sensory irritation

Jeanelle M. Martinez, Thomas E. Eling

DOI: https://doi.org/10.14573/altex.1811012

Published: Apr 18, 2019

The impact of precision uncertainty on predictive accuracy metrics of non-animal testing methods

Maria Leontaridou, Silke Gabbert, Robert Landsiedel

DOI: https://doi.org/10.14573/altex.1810111

Published: Apr 5, 2019

Opportunities for refinement in neuroscience: Indicators of wellness and post-operative pain in laboratory macaques

Kris A. Descovich, Susan E. Richmond, Matthew C. Leach, Hannah M. Buchanan-Smith, Paul Flecknell, David A. H. Farningham, Claire Witham, M. Carolyn Gates, Sarah-Jane Vick

DOI: https://doi.org/10.14573/altex.1811061

Published: Mar 29, 2019

Insights into in vitro biokinetics using Virtual Cell Based Assay simulations

Susana Proença, Alicia Paini, Elisabeth Joossens, Jose Vicente Sala Benito, Elisabet Berggren, Andrew Worth, Maurice Whelan, Pilar Prieto

DOI: https://doi.org/10.14573/altex.1812101

Published: Mar 28, 2019

Presence of vasculature results in faster insulin response in adipocytes in vascularized adipose tissue model

Outi Huttala, Jertta-Riina Sarkanen, Tuula Heinonen, Timo Ylikomi

DOI: https://doi.org/10.14573/altex.1811271

Published: Mar 15, 2019

Comparison of in chemico skin sensitization methods and development of an in chemico skin photosensitization assay

Nitin H. Patel, Priyanka K. Mishra, Rajendra Nagane, Abhay Deshpande, Irfan Y. Tamboli, Rahul Date

DOI: https://doi.org/10.14573/altex.1811011

Published: Mar 11, 2019

An in vitro coculture system for the detection of sensitization following aerosol exposure

Aline Chary, Tommaso Serchi, Elisa Moschini, Jennifer Hennen, Sebastien Cambier, Janine Ezendam, Brunhilde Blömeke, Arno C. Gutleb

DOI: https://doi.org/10.14573/altex.1901241

Published: Feb 20, 2019

How complex should an in vitro model be? Evaluation of a complex 3D alveolar model with transcriptomic data and computational biological network models

Diego Marescotti, Tommaso Serchi, Karsta Luettich, Yang Xiang, Elisa Moschini, Marja Talikka, Florian Martin, Karine Baumer, Remi Dulize, Dariusz Peric, David Bornand, Emmanuel Guedj, Alain Sewer, Sebastian Cambier, Servane Contal, Aline Chary, Arno C. Gutleb, Stefan Frentzel, Nikoloai V. Ivanov, Manuel C. Peitsch, Julia Hoeng

DOI: https://doi.org/10.14573/altex.1811221

Published: Feb 12, 2019

Improved defined approaches for predicting skin sensitization hazard and potency in humans

Haojian Li, Jing Bai, Guorui Zhong, Haosi Lin, Changsheng He, Renke Dai, Hongli Du, Lizhen Huang

DOI: https://doi.org/10.14573/altex.1809191

Published: Jan 23, 2019

A modular approach for assembly of quantitative adverse outcome pathways

Christy Foran, Taylor Rycroft, Jeffrey Keisler, Edward Perkins, Igor Linkov, Natàlia Garcia-Reyero

DOI: https://doi.org/10.14573/altex.1810181

Published: Jan 20, 2019

An intact insect embryo for developmental neurotoxicity testing of directed axonal elongation

Gregor A. Bergmann, Sarah Froembling, Nina Joseph, Karsten Bode, Gerd Bicker, Michael Stern

DOI: https://doi.org/10.14573/altex.1901292

Published: May 29, 2019

Generalized Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard

George Helman, Imran Shah, Antony J. Williams, Jeff Edwards, Jeremy Dunne, Grace Patlewicz

DOI: https://doi.org/10.14573/altex.1811292

Published: Feb 4, 2019

Advice on avoiding the Valley of Death: insights from a 3Rs model of aversive and emetic compound identification

Robin S. B. Williams, Paul L. R. Andrews

DOI: https://doi.org/10.14573/altex.1810182

Published: Apr 2, 2019

Software tools for literature screening in systematic reviews in biomedical research

Stevie van der Mierden, Katya Tsaioun, André Bleich, Cathalijn H. C. Leenaars

DOI: https://doi.org/10.14573/altex.1902131

Published: May 16, 2019