Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Developing context appropriate toxicity testing approaches using new alternative methods (NAMs)

Melvin E. Andersen, Patrick D. McMullen, Martin B. Phillips, Miyoung Yoon, Salil N. Pendse, Harvey J. Clewell, Jessica K. Hartman, Marjory Moreau, Richard A. Becker, Rebecca A. Clewell

DOI: https://doi.org/10.14573/altex.1906261

Published: Oct 12, 2019

Development of an ex vivo aneurysm model for vascular devices testing

Noemi Vanerio, Marco Stijnen, Bas A. J. M. de Mol, Linda M. Kock

DOI: https://doi.org/10.14573/altex.1906253

Published: Oct 23, 2019

Multilayered fibroblasts constructed by accelerated cellular self-assembly and applications for regenerative medicine

Paninee Chetprayoon, Sasitorn Aueviriyavit, Arisara Prateep, Sirima Boonjing, Rawiwan Maniratanachote

DOI: https://doi.org/10.14573/altex.1904032

Published: Oct 2, 2019

A novel approach to increase robustness, precision and high-throughput capacity of single cell gel electrophoresis

Juan C. Cassano, Matthias Roesslein, Rolf Kaufmann, Thomas Luethi, Oliver Schicht, Peter Wick, Cordula Hirsch

DOI: https://doi.org/10.14573/altex.1906252

Published: Aug 28, 2019

AOPERA: A proposed methodology and inventory of effective tools to link chemicals to adverse outcome pathways

Taylor E. Rycroft, Christy M. Foran, Adam Thrash, Jeffrey C. Cegan, Robert Zollinger, Igor Linkov, Edward J. Perkins, Natàlia Garcia-Reyero

DOI: https://doi.org/10.14573/altex.1906201

Published: Aug 26, 2019

3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology

Carine Poussin, Bart Kramer, Henriette L. Lanz, Angelique van den Heuvel, Alexandra Laurent, Thomas Olivier, Marjolein Vermeer, Dariusz Peric, Karine Baumer, Rémi Dulize, Emmanuel Guedj, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng, Jos Joore

DOI: https://doi.org/10.14573/altex.1811301

Published: Aug 22, 2019

Extending the concept of predicting fish acute toxicity in vitro to the intestinal cell line RTgutGC

Hannah Schug, Jenny Maner, Maren Hülskamp, Frédéric Begnaud, Christian Debonneville, Fabienne Berthaud, Sylvia Gimeno, Kristin Schirmer

DOI: https://doi.org/10.14573/altex.1905032

Published: Jul 11, 2019

Machine learning prediction of cyanobacterial toxin (microcystin) toxicodynamics in humans

Stefan Altaner, Sabrina Jaeger, Regina Fotler, Ivan Zemskov, Valentin Wittmann, Falk Schreiber, Daniel R. Dietrich

DOI: https://doi.org/10.14573/altex.1904031

Published: Jul 2, 2019

Innovative in vitro method to study ventilator induced lung injury

Jon P. Joelsson, Iwona T. Myszor, Ari J. Arason, Saevar Ingthorsson, Paulina Cherek, Gabriel S. Windels, Kristjan Leosson, Gudmundur H. Gudmundsson, Thorarinn Gudjonsson, Sigurbergur Karason

DOI: https://doi.org/10.14573/altex.1901182

Published: Jun 5, 2019

Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model

Stefania Serra, Monica Vaccari, Maria Grazia Mascolo, Francesca Rotondo, Cristina Zanzi, Laura Polacchini, Christine Behle Wagner, Thorsten Kunkelmann, Sabine Perschbacher, Albrecht Poth, Sandro Grilli, Miriam N. Jacobs, Annamaria Colacci

DOI: https://doi.org/10.14573/altex.1812173

Published: Jun 3, 2019

The HaCaT/THP-1 Cocultured Activation Test (COCAT) for skin sensitization: a study of intra-laboratory reproducibility and predictivity

Chantra Eskes, Jennifer Hennen, Mario Schellenberger, Sebastian Hoffmann, Sabine Frey, Daniela Goldinger-Oggier, Niklas Peter, Erwin van Vliet, Brunhilde Blömeke

DOI: https://doi.org/10.14573/altex.1905031

Published: May 27, 2019

Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing

James C. Y. Chan, Shawn P. F. Tan, Zee Upton, Eric C. Y. Chan

DOI: https://doi.org/10.14573/altex.1812051

Published: May 10, 2019

Assessment of iron oxide nanoparticle ecotoxicity on regeneration and homeostasis in the replacement model system Schmidtea mediterranea

Thao A. Tran, Michelle Hesler, Oscar H. Moriones, Alba Jimeno-Romero, Benjamin Fischer, Neus G. Bastús, Victor Puntes, Sylvia Wagner, Yvonne L. Kohl, Luca Gentile

DOI: https://doi.org/10.14573/altex.1902061

Published: Apr 26, 2019

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition

Jie Mei, Stefanie Banneke, Janet Lips, Melanie T. C. Kuffner, Christian J. Hoffmann, Ulrich Dirnagl, Matthias Endres, Christoph Harms, Julius V. Emmrich

DOI: https://doi.org/10.14573/altex.1812231

Published: Apr 18, 2019

Activation of TRPA1 by volatile organic chemicals leading to sensory irritation

Jeanelle M. Martinez, Thomas E. Eling

DOI: https://doi.org/10.14573/altex.1811012

Published: Apr 18, 2019

Opportunities for refinement in neuroscience: Indicators of wellness and post-operative pain in laboratory macaques

Kris A. Descovich, Susan E. Richmond, Matthew C. Leach, Hannah M. Buchanan-Smith, Paul Flecknell, David A. H. Farningham, Claire Witham, M. Carolyn Gates, Sarah-Jane Vick

DOI: https://doi.org/10.14573/altex.1811061

Published: Mar 29, 2019

An intact insect embryo for developmental neurotoxicity testing of directed axonal elongation

Gregor A. Bergmann, Sarah Froembling, Nina Joseph, Karsten Bode, Gerd Bicker, Michael Stern

DOI: https://doi.org/10.14573/altex.1901292

Published: May 29, 2019

Organ-on-chip in development
Towards a roadmap for organs-on-chip

Massimo Mastrangeli, Sylvie Millet, The ORCHID partners, Janny van den Eijnden-van Raaij

DOI: https://doi.org/10.14573/altex.1908271

Published: Oct 14, 2019