Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)

Szczepan W. Baran, Paul C. Brown, Andreas R. Baudy, Suzanne C. Fitzpatrick, Christopher Frantz, Aaron Fullerton, Jinping Gan, Rhiannon N. Hardwick, Kathleen M. Hillgren, Anna K. Kopec, Jennifer L. Liras, Donna L. Mendrick, Ryan Nagao, William R. Proctor, Diane Ramsden, Alexandre J. S. Ribeiro, David Stresser, Kyung E. Sung, Radhakrishna Sura, Kazuhiro Tetsuka, Lindsay Tomlinson, Terry Van Vleet, Matthew P. Wagoner, Qin Wang, Sevim Yildiz Arslan, Gorm Yoder, Jason E. Ekert
Published: Jan 21, 2022

Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data

Ans Punt, Jochem Louisse, Karsten Beekmann, Nicole Pinckaers, Eric Fabian, Bennard van Ravenzwaay, Paul L. Carmichael, Ian Sorrell, Thomas E. Moxon
Published: Jan 19, 2022

Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid

Nanette G. Vrijenhoek, Matthias M. Wehr, Steven J. Kunnen, Lukas S. Wijaya, Giulia Callegaro, Martijn J. Moné, Sylvia E. Escher, Bob van de Water
Published: Jan 17, 2022

In vitro models of the canine digestive tract as an alternative to in vivo assays: Advances and current challenges

Charlotte Deschamps, Sylvain Denis, Delphine Humbert, Jürgen Zentek, Nathalie Priymenko, Emmanuelle Apper, Stéphanie Blanquet
Published: Jan 13, 2022

COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop.

Laure-Alix Clerbaux, Núria Amigó, Maria João Amorim, Anna Bal-Price, Sofia Batista Leite, Anna Beronius, Gillina F. G. Bezemer, Ann-Charlotte Bostroem, Annamaria Carusi, Sandra Coecke, Rachel Concha, Evangelos P. Daskalopoulos, Francesca Debernardi, Eizleayne Edrosa, Steve W. Edwards, Julija Filipovska, Natàlia Garcia-Reyero, Felicity N. E. Gavins, Sabina Halappanavar, Alan J. Hargreaves, Helena T. Hogberg, Mylène T. Huynh, Daniel Jacobson, Jonathan Josephs-Spaulding, Young Jun Kim, Hyun Joon Kong, Catharine E. Krebs, Ann Lam, Brigitte Landesmann, Adrienne Racanelli Layton, Yong Oh Lee, Donna S. Macmillan, Alberto Mantovani, Luigi Margiotta-Casaluci, Marvin Martens, Rosalinde Masereeuw, Sally A. Mayasich, Liang Merlin Mei, Holly Mortensen, Amalia Munoz Pineiro, Penny Nymark, Elan Ohayon, Joshi Manoj Ojasi, Alicia Paini, Nikolaos Parissis, Surat Parvatam, Francesca Pistollato, Magdalini Sachana, Jorid Birkelund Sørli, Kristie M. Sullivan, Jukka Sund, Shihori Tanabe, Katya Tsaioun, Mathieu Vinken, Laura Viviani, Jennifer Waspe, Catherine Willett, Clemens Wittwehr
Published: Jan 3, 2022

Potential of concentration-response data to broaden regulatory application of in vitro test guidelines

Miriam N. Jacobs, Janine Ezendam, Betty Hakkert, Michael Oelgeschlaeger
Published: Dec 9, 2021

U.S. federal agency interests and key considerations for new approach methodologies for nanomaterials

Elijah J. Petersen, Patricia Ceger, David G. Allen, Jayme Coyle, Raymond Derk, Natalia Garcia-Reyero, John Gordon, Nicole Kleinstreuer, Joanna Matheson, Danielle McShan, Bryant C. Nelson, Anil K. Patri, Penelope Rice, Liying Rojanasakul, Abhilash Sasidharan, Louis Scarano, Xiaoqing Chang
Published: Dec 3, 2021

Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics

Diane Ramsden, David G. Belair, Saket Agarwal, Patrik Andersson, Sara Humphreys, Deidre A. Dalmas, Simone H. Stahl, Chris Maclauchlin, Joseph A. Cichocki
Published: Nov 11, 2021

Systematic review in evidence-based risk assessment

Nawal Farhat, Katya Tsaioun, Patrick Saunders-Hastings, Rebecca L Morgan, Siva Ramoju, Thomas Hartung, Daniel Krewski
Published: Sep 27, 2021