Latest Articles

Latest Articles

Latest Articles are manuscripts that have recently been accepted for publication in ALTEX but have not yet undergone editing, layout, and proofreading. They are replaced by a final version with the same doi upon print publication in an issue of ALTEX.

Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens

Sylvia E. Escher, Susan P. Felter, Heli Hollnagel, Alan R. Boobis, Chihae Yang, James Rathman, Mark T. D. Cronin, Monika Batke
Published: Nov 11, 2022

Report on 2021 International Workshop for Non-animal Approaches in the Food Sector (Japan): Current status and avenues for further research

Satoshi Ohta, Shigeki Kimura, Daisuke Maejima, Kazutoshi Saito, Yasuhiro Tanaka, Satoshi Kojima, Tomohiro Kawaguchi, Takuya Kikuchi, Takuya Seki, Hsuan Chung, Risa Funaki, Tetsuya Kuhara, Hisako Hori, Yuichi Ito
Published: Nov 10, 2022

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells

Anouck Thienpont, Stefaan Verhulst, Leo A. van Grunsven, Vera Rogiers, Tamara Vanhaecke, Birgit Mertens
Published: Nov 4, 2022

The GARD™skin assay: Investigation of the applicability domain for metals

Andy Forreryd, Robin Gradin, Olivia Larne, Nissanka Rajapakse, Eliot Deag, Henrik Johansson
Published: Nov 3, 2022

Proceedings of a workshop to address animal methods bias in scientific publishing

Catharine E. Krebs, Celean Camp, Helder Constantino, Lilas Courtot, Owen Kavanagh, Sofia Batista Leite, Judith Madden, Alicia Paini, Brinda Poojary, Ignacio J. Tripodi, Emily R. Trunnell
Published: Oct 31, 2022

Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells

Keith A. Houck, Katie Paul Friedman, Madison Feshuk, Grace Patlewicz, Marci Smeltz, M. Scott Clifton, Barbara A. Wetmore, Sharlene Velichko, Antal Berenyi, Ellen L. Berg
Published: Sep 15, 2022

Application of immunocompetent microphysiological systems in drug development: Current perspective and recommendations

Xiaoting Wang, Anna K. Kopec, Mark Collinge, Rhiannon David, Christian Grant, Rhiannon N. Hardwick, Aaron Navratil, Nirav Patel, Wendy Rowan, Nikki Marshall
Published: Aug 29, 2022

Technical framework for enabling high-quality measurements in new approach methodologies (NAMs)

Elijah J. Petersen, John T. Elliott, John Gordon, Nicole C. Kleinstreuer, Emily Reinke, Mattias Roesslein, Blaza Toman
Published: Jul 15, 2022

Comparison of pyrogen assays by testing products exhibiting low endotoxin recovery

Tammy L. Thurman, Carol J. Lahti, Jeanne M. Mateffy, Ren-Yo Forng, Friedrich von Wintzingerode, Lindsey M. Silva, Sven M. Deutschmann, Ned M. Mozier
Published: Jun 24, 2022

How to formulate hypotheses and IATAs to support grouping and read-across of nanoforms

Fiona A. Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristo, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone
Published: Jun 22, 2022

A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level

Diana Karwelat, Julia Kühnlenz, Thomas Steger-Hartmann, Remi Bars, Helen Tinwell, Uwe Marx, Sophie Bauer, Oliver Born, Marian Raschke
Published: Jun 21, 2022

Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing

Mark C. Daley, Ulrike Mende, Bum-Rak Choi, Patrick D. McMullen, Kareen L. K. Coulombe
Published: Jun 1, 2022

Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment

Alex N. Cayley, Robert S. Foster, Emma Hill, Steven Kane, Grace Kocks, Alun Myden, Daniel Newman, Susanne A. Stalford, Jonathan D. Vessey, Reza Zarei, Antonio Anax F. de Oliveira
Published: May 13, 2022

A microfluidic thyroid-liver platform to assess chemical safety in humans

Julia Kühnlenz, Diana Karwelat, Thomas Steger-Hartmann, Marian Raschke, Sophie Bauer, Özlem Vural, Uwe Marx, Helen Tinwell, Remi Bars
Published: May 9, 2022

Exploration of the GARD™skin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs

Andy Forreryd, Robin Gradin, Charles Humfrey, Len Sweet, Henrik Johansson
Published: Apr 21, 2022

A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells

Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa, Takayuki Yoshimoto
Published: Feb 24, 2022