Latest Articles | ALTEX - Alternatives to animal experimentation

In vitro-based prediction of human plasma concentrations of food-related compounds

Takashi Kitaguchi, Mina Ito, Katsutoshi Ohno, Noriaki Ota, Kazuhiro Kobayashi, Hiromi Sato, Takahiro Iwao, Tamihide Matsunaga, Mitsuru Tanaka, Akihiro Hisaka

DOI: https://doi.org/10.14573/altex.2302131

Published: May 12, 2023

accepted manuscript sup

Comparing translational success rates across medical research fields
A combined analysis of literature and clinical trial data

Gwen Van de Wall, Astrid van Hattem, Joy Timmermans, Merel Ritskes-Hoitinga, André Bleich, Cathalijn Leenaars

DOI: https://doi.org/10.14573/altex.2208261

Published: May 5, 2023

accepted manuscript sup

A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides

Kristina Bartmann, Farina Bendt, Arif Dönmez, Daniel Haag, H. Eike Keßel, Stefan Masjosthusmann, Christopher Noel, Ji Wu, Peng Zhou, Ellen Fritsche

DOI: https://doi.org/10.14573/altex.2206031

Published: May 3, 2023

accepted manuscript sup1 sup2

Development of physiologically-based gut absorption model for probabilistic prediction of environmental chemical bioavailability

Hsing-Chieh Lin, Weihsueh A. Chiu

DOI: https://doi.org/10.14573/altex.2210031

Published: May 3, 2023

accepted manuscript sup

Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment

Andreas Natsch

DOI: https://doi.org/10.14573/altex.2302081

Published: Apr 17, 2023

accepted manuscript ESM1 ESM2 ESM3

Applying a next generation risk assessment framework for skin sensitisation to inconsistent new approach methodology information

Nicola Gilmour, Nathalie Alépée, Sebastian Hoffmann, Petra Kern, Erwin Van Vliet, Dagmar Bury, Masaaki Miyazawa, Hayato Nishida, Cosmetics Europe

DOI: https://doi.org/10.14573/altex.2211161

Published: Mar 14, 2023

accepted manuscript

Challenges and opportunities for overcoming dog use in agrochemical evaluation and registration

Patricia L. Bishop, Susy Brescia, Rachel Brunner, Warren Casey, Kathleen Conlee-Griffin, Richard A. Currie, Jeanne Domoradzki, Michelle Embry, Maria Ines Harris, Thomas Hartung, Gina M. Hilton, Barry Hooberman, Brandall Ingle, Kyung-Jin Jang, Lewis Kinter, Caroline Krall, Joseph Leedale, Anna Lowit, Jyotigna Mehta, Elizabeth Mendez, Bob Mingoia, Eliana Munarriz, Lynea Murphy, Angela Myer, Antoniana Ottoni, Martina Panzarea, Monique Perron, Juan Pina, Deborah Ramsingh, Fiona Sewell, Jennifer Swanson, Yu-Mei Tan, Andrea Terron, Maria A. Trainer, Marize Campos Valadares, Steven Webb, Elizabeth Webb, Catherine Willett, Douglas C. Wolf

DOI: https://doi.org/10.14573/altex.2302151

Published: Mar 8, 2023

accepted manuscript

Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment

Jan Turner, Pandora Pound, Carla Owen, Isobel Hutchinson, Marina Hop, David Y. S. Chau, Lady V. Barrios Silva, Mike Coleman, Audrey Dubourg, Lorna W. Harries, Victoria Hutter, J- Gerry Kenna, Volker M. Lauschke, Winfried Neuhaus, Clive Roper, Paul B. Watkins, Jonathan Welch, Laura R. Alvarez, Katy Taylor

DOI: https://doi.org/10.14573/altex.2212081

Published: Jan 18, 2023

accepted manuscript sup

Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges

Onyi Irrechukwu, Ronnie Yeager, Rhiannon David, Jason Ekert, Anitha Saravanakumar, Colin K. Choi

DOI: https://doi.org/10.14573/altex.2204071

Published: Jan 12, 2023

accepted manuscript

The GARD™skin assay: Investigation of the applicability domain for metals

Andy Forreryd, Robin Gradin, Olivia Larne, Nissanka Rajapakse, Eliot Deag, Henrik Johansson

DOI: https://doi.org/10.14573/altex.2203021

Published: Nov 3, 2022

accepted manuscript sup

Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion

Pedro Caetano-Pinto, Pär Nordell, Tom Nieskens, Katie Haughan, Katherine S. Fenner, Simone H. Stahl

DOI: https://doi.org/10.14573/altex.2204011

Published: Nov 3, 2022

accepted manuscript sup

Proceedings of a workshop to address animal methods bias in scientific publishing

Catharine E. Krebs, Celean Camp, Helder Constantino, Lilas Courtot, Owen Kavanagh, Sofia Batista Leite, Judith Madden, Alicia Paini, Brinda Poojary, Ignacio J. Tripodi, Emily R. Trunnell

DOI: https://doi.org/10.14573/altex.2210211

Published: Oct 31, 2022

accepted manuscript sup