[Detection of extraneous virus in live vaccines] [Article in German]

Beate Krämer; Petra Rübmann; Karin Duchow; Klaus Cussler

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Published: Jan 1, 1998

Beate Krämer, Petra Rübmann, Karin Duchow, Klaus Cussler
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Abstract

In the study in vitro alternatives to a nonvalidated and harmful animal test for the absence of extraneous virus in live vaccines were investigated.
For evaluation of a suitable in vitro method the porcine herpesvirus (Aujeszkyvirus, Pseudorabiesvirus) was used as a model virus. In artificially contaminated live vaccines the aujeszkyvirus could be detected by moleculargenetical and cellular methods. Regarding the threshold values of virus detection in vitro tests showed to be more efficacious than animal testing.
Meanwhile the European Pharmacopoeia Commission deleted the animal test for extraneous virus from two monographs. The discussion, if respective animal testing can be cancelled for the other live vaccines as well, is still ongoing.
The study was supported by the German Ministry of Education, Science, Research and Technology.

How to Cite

Krämer, B. (1998) “[Detection of extraneous virus in live vaccines] [Article in German]”, ALTEX - Alternatives to animal experimentation, 15(Supp. 1), pp. 43–45. Available at: https://www.altex.org/index.php/altex/article/view/2093 (Accessed: 27 April 2024).

Issue

Vol. 15 No. Supp. 1 (1998): 2. Paul-Ehrlich-Seminar über Tierschutzaspekte bei der Zulassung und Prüfung von immunologischen Arzneimitteln

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Articles are distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is appropriately cited (CC-BY). Copyright on any article in ALTEX is retained by the author(s).

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