[Development of an in vitro assay for the detection of Botulinum Neurotoxins - preliminary results] [Article in German]

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Published: Jan 1, 1998

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Frank Gessler, Susanne Behrens, Petra Loch, Helge Böhnel
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Abstract

Botulism is a severe, often lethal intoxication, which affects man and animal. It is caused by the neurotoxins (BoNT) of Clostridium botulinum, an anaerobic spore-former. At present the toxin types A-G have been identified. The extreme toxicity of these substances still make the animal testing inevitable. No alternative method could reach the sensitivity of the mouse bioassay. Based on the investigations presented, a serological test shall be developed, which concentrates the sample and detects the toxin in one step. Preliminary results of an in vitro test detecting BoNT/D are discussed.

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How to Cite
Gessler, F. (1998) “[Development of an in vitro assay for the detection of Botulinum Neurotoxins - preliminary results] [Article in German]”, ALTEX - Alternatives to animal experimentation, 15(Supp. 1), pp. 62–64. Available at: https://www.altex.org/index.php/altex/article/view/2099 (Accessed: 26 April 2024).
Issue
Vol. 15 No. Supp. 1 (1998): 2. Paul-Ehrlich-Seminar über Tierschutzaspekte bei der Zulassung und Prüfung von immunologischen Arzneimitteln
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