Editorial

Sonja von Aulock

U2

Alternative acute oral toxicity assessment under REACH based on sub-acute toxicity values

Andrea Gissi, Kimmo Louekari, Laurence Hoffstadt, Norbert Bornatowicz, Alberto M. Aparicio

353-361

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

David Pamies, Paula Barreras, Katharina Block, Georgia Makri, Anupama Kumar, Daphne Wiersma, Lena Smirnova, Ce Zhang, Joseph Bressler, Kimberly M. Christian, Georgina Harris, Guo-li Ming, Cindy J. Berlinicke, Kelly Kyro, Hongjun Song, Carlos A. Pardo, Thomas Hartung, Helena T. Hogberg

362-376

Incorporation of a metabolizing system in biodetection assays for endocrine active substances

Julie Mollergues, Barbara van Vugt-Lussenburg, Christian Kirchnawy, Reka Anna Bandi, Rosan B. van der Lee, Maricel Marin-Kuan, Benoit Schilter, Karma C. Fussell

389-398

In vitro to in vivo extrapolation for drug-induced liver injury using a pair ranking method

Zhichao Liu, Hong Fang, Jürgen Borlak, Ruth Roberts, Weida Tong

399-408

Facial expression: An under-utilized tool for the assessment of welfare in mammals

Kris A. Descovich, Jennifer Wathan, Matthew C. Leach, Hannah M. Buchanan-Smith, Paul Flecknell, David Farningham, Sarah-Jane Vick

409-429

In vitro eye irritation testing using the open source reconstructed hemicornea – a ring trial

Karsten R. Mewes, Maria Engelke, Michaela Zorn-Kruppa, Melinda Bartok, Rashmi Tandon, Johanna M. Brandner, Dirk Petersohn

430-434

IN vitro toxicology: From INtestine to braIN

Claudia D. Gherman, Cornel Catoi, Carmen Socaciu, Adela Pintea, Nechita A. Oros, Flaviu Tabaran, Andras-Laszlo Nagy, Yula Sambuy, Isabella De Angelis, Teresa Coccini, Virginia Bassi, Francesca Caloni

439-440

Alternative approach to animal testing and cell cultures, according to European laws

Chiara Scanarotti, Costanza Rovida, Susanna Penco, Stefania Vernazza, Sara Tirendi, Rosagemma Ciliberti, Anna Maria Bassi

441-442