[Monoclonal antibodies: in vivo and in vitro production in laboratory scale with consideration of the legal aspects of animal protection] [Article in German]

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Ingrid Kuhlmann
Waltraud Kurth
Irmela Ruhdel

Abstract

Monoclonal antibodies are valuable tools in medical and biological research which can be used for identifying, characterising and purifying medically and biologically important substances. Due to their high specificity monoclonal antibodies are more and more used in the diagnosis and therapy of infectious diseases and tumour illnesses. Large amounts of antibodies are needed for use in these areas and this necessitates mass production (g - kg range). Many production systems and possibilities for optimising mass production have been described. In contrast, at universities and other research institutions the production of monoclonal antibodies in laboratory scale (mg range) is still carried out mostly in the ascites mouse. This article described our own experiences and results with the in vitro production in mg range. Using the German animal protection law (8/22/1986) as an example the legal aspects of animal protection in the production of monoclonal antibodies are discussed. In addition the legal regulations in Switzerland and the Netherlands are presented.

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How to Cite
Kuhlmann, I., Kurth, W. and Ruhdel, I. (1989) “[Monoclonal antibodies: in vivo and in vitro production in laboratory scale with consideration of the legal aspects of animal protection] [Article in German]”, ALTEX - Alternatives to animal experimentation, 6(2), pp. 12–26. Available at: https://www.altex.org/index.php/altex/article/view/1882 (Accessed: 2 October 2022).
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