The Human Toxome Project

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Mounir Bouhifd
Melvin E. Andersen
Christina Baghdikian
Kim Boekelheide
Kevin M. Crofton
Albert J. Fornace Jr.
Andre Kleensang
Henghong Li
Carolina Livi
Alexandra Maertens
Patrick D. McMullen
Michael Rosenberg
Russell Thomas
Marguerite Vantangoli
James D. Yager
Liang Zhao
Thomas Hartung

Abstract

The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies.

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How to Cite
Bouhifd, M., Andersen, M. E., Baghdikian, C., Boekelheide, K., Crofton, K. M., Fornace Jr., A. J., Kleensang, A., Li, H., Livi, C., Maertens, A., McMullen, P. D., Rosenberg, M., Thomas, R., Vantangoli, M., Yager, J. D., Zhao, L. and Hartung, T. (2015) “The Human Toxome Project”, ALTEX - Alternatives to animal experimentation, 32(2), pp. 112-124. doi: 10.14573/altex.1502091.
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