Editorial

Sonja von Aulock

U2

Introducing the concept of virtual control groups into preclinical toxicology testing

Thomas Steger-Hartmann, Annika Kreuchwig, Lea Vaas, Jörg Wichard, Frank Bringezu, Alexander Amberg, Wolfgang Muster, Francois Pognan, Chris Barber

343-349

Modeling chemotherapy-induced peripheral neuropathy using a nerve-on-a-chip microphysiological system

Liana Kramer, Hieu T. Nguyen, Elizabeth Jacobs, Laurie McCoy, J. Lowry Curley, Anup D. Sharma, Michael J. Moore

350-364

Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

Uwe Marx, Takafumi Akabane, Tommy B. Andersson, Elizabeth Baker, Mario Beilmann, Sonja Beken, Susanne Brendler-Schwaab, Murat Cirit, Rhiannon David, Eva-Maria Dehne, Isabell Durieux, Lorna Ewart, Suzanne C. Fitzpatrick, Olivier Frey, Florian Fuchs, Linda G. Griffith, Geraldine A. Hamilton, Thomas Hartung, Julia Hoeng, Helena Hogberg, David J. Hughes, Donald E. Ingber, Anita Iskandar, Toshiyuki Kanamori, Hajime Kojima, Jochen Kuehnl, Marcel Leist, Bo Li, Peter Loskill, Donna L. Mendrick, Thomas Neumann, Giorgia Pallocca, Ivan Rusyn, Lena Smirnova, Thomas Steger-Hartmann, Danilo A. Tagle, Alexander Tonevitsky, Sergej Tsyb, Martin Trapecar, Bob van de Water, Janny van den Eijnden-van Raaij, Paul Vulto, Kengo Watanabe, Armin Wolf, Xiaobing Zhou, Adrian Roth

365-394

Towards an animal-free human health assessment: Starting from the current regulatory needs

Peter M. J. Bos, Liesbeth Geraets, Lianne de Wit-Bos, Minne Heringa, Jacqueline van Engelen

395-408

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

Markus Brüll, Anna-Sophie Spreng, Simon Gutbier, Dominik Loser, Alice Krebs, Marvin Reich, Udo Kraushaar, Markus Britschgi, Christoph Patsch, Marcel Leist

409-428

Inflammation-induced tissue damage mimicking GvHD in human skin models as test platform for immunotherapeutics

Julia Wallstabe, Lydia Bussemer, Florian Groeber-Becker, Lukas Freund, Miriam Alb, Mariola Dragan, Ana Maria Waaga-Gasser, Rafael Jakubietz, Hermann Kneitz, Andreas Rosenwald, Silke Rebhan, Heike Walles, Stephan Mielke

429-440

Evaluation of phototoxic and cytotoxic potential of TiO2 nanosheets in a 3D reconstructed human skin model

Alžbeta Líšková, Silvia Letašiová, Soňa Jantová, Vlasta Brezová, Helena Kandárová

441-450

Automated integration of structural, biological and metabolic similarities to improve read-across

Domenico Gadaleta, Azadi Golbamaki Bakhtyari, Giovanna J. Lavado, Alessandra Roncaglioni, Emilio Benfenati

469-481

Strategy to replace animal-derived ECM by a modular and highly defined matrix

Yevheniia Nesterenko, Xenia Dolde, Marcel Leist, Olga Mayans

482-489

Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0) – Draft for stakeholder discussion and call for action

David Pamies, Marcel Leist, Sandra Coecke, Gerard Bowe, Dave Allen, Gerhard Gstraunthaler, Anna Bal-Price, Francesca Pistollato, Rob deVries, Thomas Hartung, Glyn Stacey

490-492

2nd Centro3R Annual Meeting: 3Rs in Italian universities

Anna M. Bassi, Arti Ahluwalia, Susanna Penco, Valeria Chiono, Gianfranco B. Fiore, Livia Visai

493-495

Virtual Summer School: Alternative methods and models in science: A multidisciplinary in vitro approach

Francesca Caloni, Alessandra Cazzaniga, Teresa Coccini, Arno C. Gutleb, Helena Kandárová , Marisa Meloni, Hassan Rashidi, Yula Sambuy, Doris Wilflingseder, Giulio Casati

500-502

Setting the trend for the alternatives movement in India: The Second National Conference of the Society for Alternatives to Animal Experiments-India

Pratiksha Palahe, Shalmali Pendse, Vinal Pardhi, Vikas Jha, Valencia D'souza, Sreejith P. Panicker, Sheikh Raisuddin, Mohammad A. Akbarsha

503-506

Corrigendum to An advanced in vitro model to assess glaucoma onset

Sergio C. Saccà, Sara Tirendi, Sonia Scarfì, Mario Passalacqua, Francesco Oddone, Carlo E. Traverso, Stefania Vernazza, Anna M. Bassi

492

Corners

Sonja von Aulock

507-516

Imprint

Sonja von Aulock

U3

Cover

Sonja von Aulock

U1-U4