Making better use of toxicity studies for human health by extrapolating across endpoints

Federica Madia, Raffaella Corvi, Andrew Worth, Izabela Matys, Pilar Prieto

519-531

Optimization of the monocyte activation test for evaluating pyrogenicity of tick-borne encephalitis virus vaccine

Marilena P. Etna, Elena Giacomini, Fabiana Rizzo, Martina Severa, Daniela Ricci, Shahjahan Shaid, Denis Lambrigts, Sara Valentini, Luisa Galli Stampino, Liliana Alleri, Andrea Gaggioli, Christina von Hunolstein, Ingo Spreitzer, Eliana M. Coccia

532-544

Azithromycin has lung barrier protective effects in a cell model mimicking ventilator-induced lung injury

Jon P. Joelsson, Iwona T. Myszor, Snaevar Sigurdsson, Fredrik Lehmann, Clive P. Page, Gudmundur H. Gudmundsson, Thorarinn Gudjonsson, Sigurbergur Karason

545-560

The in vitro human fracture hematoma model – a tool for preclinical drug testing

Moritz Pfeiffenberger, Paula Hoff, Christa Thöne-Reineke, Frank Buttgereit, Annemarie Lang, Timo Gaber

561-578

Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology

Costanza Rovida, Tara Barton-Maclaren, Emilio Benfenati, Francesca Caloni, P. Charukeshi Chandrasekera, Christophe Chesné, Mark T. D. Cronin, Joop De Knecht, Daniel R. Dietrich, Sylvia E. Escher, Suzanne Fitzpatrick, Brenna Flannery, Matthias Herzler, Susanne Hougaard Bennekou, Bruno Hubesch, Hennicke Kamp, Jaffar Kisitu, Nicole Kleinstreuer, Simona Kovarich, Marcel Leist, Alexandra Maertens, Kerry Nugent, Giorgia Pallocca, Manuel Pastor, Grace Patlewicz, Manuela Pavan, Octavio Presgrave, Lena Smirnova, Michael Schwarz, Takashi Yamada, Thomas Hartung

579-606

New approach methodologies (NAMs) for human-relevant biokinetics predictions

Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment

Ans Punt, Hans Bouwmeester, Bas J. Blaauboer, Sandra Coecke, Betty Hakkert, Delilah F. G. Hendriks, Paul Jennings, Nynke I. Kramer, Sibylle Neuhoff, Rosalinde Masereeuw, Alicia Paini, Ad A. C. M. Peijnenburg, Martijn Rooseboom, Michael L. Shuler, Ian Sorrell, Bart Spee, Marije Strikwold, Andries D. van der Meer, Meike van der Zande, Mathieu Vinken, Huan Yang, Peter M. J. Bos, Minne B. Heringa

607-622

The kinetic direct peptide reactivity assay (kDPRA): Intra- and inter-laboratory reproducibility in a seven-laboratory ring trial

Britta Wareing, Susanne N. Kolle, Barbara Birk, Nathalie Alépée, Tina Haupt, Rishil Kathawala, Petra S. Kern, Laurent Nardelli, Hans Raabe, Marián Rucki, Cindy A. Ryan, Sjoerd Verkaart, Walter M. A. Westerink, Robert Landsiedel, Andreas Natsch

639-651

Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2

C. Korin Bullen, Helena T. Hogberg, Asli Bahadirli-Talbott, William R. Bishai, Thomas Hartung, Casey Keuthan, Monika M. Looney, Andrew Pekosz, J. Carolina Romero, Fenna C. M. Sillé, Peter Um, Lena Smirnova

665-671

Non-aversive mouse handling techniques: A survey on the acceptance and concerns of the animal facility and scientific staff

Katharina Hohlbaum, Melanie Humpenöder, Stefan Nagel-Riedasch, Kristina Ullmann, Christa Thöne-Reineke

671-674

Increasing the availability of quality human tissue for research

Janine McCarthy, Edward LeCluyse, Sharon Presnell, Gina Dunne Smith, Timothy L. Pruett, Ann Lam, Elizabeth Baker, Thomas Buersmeyer, Kristie Sullivan

674-681

Innovative in vitro strategies for food and environmental safety

Susanna Alloisio, Alessia Bertero, Francesca Caloni, Isabella De Angelis, Cristina Scarone, Francesco Misurale, Valentina Prota, Nathalie Steimberg, Olimpia Vincentini, Diego Baderna

681-683

Corners

Sonja von Aulock

685-692

Chemical concentrations in cell culture compartments (C5) – free concentrations

Jaffar Kisitu, Henner Hollert, Ciarán Fisher, Marcel Leist

693-708

Imprint

Sonja von Aulock

U3

Cover

Sonja von Aulock

U1-U4