Editorial

Sonja von Aulock

U2

Read-across approaches – misconceptions, promises and challenges ahead

Grace Patlewicz, Nicholas Ball, Richard A. Becker, Ewan D. Booth, Mark T. D. Cronin, Dinant Kroese, David Steup, Ben van Ravenzwaay, Thomas Hartung

387-396

A human dendritic cell-based in vitro model to assess Mycobacterium tuberculosis SO2 vaccine immunogenicity

Marilena P. Etna, Elena Giacomini, Martina Severa, Manuela Pardini, Nacho Aguilo, Carlos Martin, Eliana M. Coccia

397-406

Pathway-based toxicity: History, current approaches, and liver fibrosis and steatosis as prototypes

Catherine Willett, Jessica Caverly Rae, Katy O. Goyak, Brigitte Landesmann, Gary Minsavage, Carl Westmoreland

407-421

A k-NN algorithm for predicting oral sub-chronic toxicity in the rat

Domenico Gadaleta, Fabiola Pizzo, Anna Lombardo, Angelo Carotti, Sylvia E. Escher, Orazio Nicolotti, Emilio Benfenati

423-432

Spinal cord – skeletal muscle cocultures detect muscle-relaxant action of botulinum neurotoxin A

Veit-Simon Eckle, Berthold Drexler, Christian Grasshoff, Thomas Seeger, Horst Thiermann, Bernd Antkowiak

433-440

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Natalie Alépée, Anthony Bahinski, Mardas Daneshian, Bart De Wever, Ellen Fritsche, Alan Goldberg, Jan Hansmann, Thomas Hartung, John Haycock, Helena T. Hogberg, Lisa Hoelting, Jens M. Kelm, Suzanne Kadereit, Emily McVey, Robert Landsiedel, Marcel Leist, Marc Lübberstedt, Fozia Noor, Christian Pellevoisin, Dirk Petersohn, Uwe Pfannenbecker, Kerstin Reisinger, Tzutzuy Ramirez, Barbara Rothen-Rutishauser, Monika Schäfer-Korting, Katrin Zeilinger, Marie-Gabriele Zurich

441-477

Current approaches and future role of high content imaging in safety sciences and drug discovery

Erwin van Vliet, Mardas Daneshian, Mario Beilmann, Anthony Davies, Eugenio Fava, Roland Fleck, Yvon Julé, Manfred Kansy, Stefan Kustermann, Peter Macko, William R. Mundy, Adrian Roth, Imran Shah, Marianne Uteng, Bob van de Water, Thomas Hartung, Marcel Leist

479-493

The use of artificial crabs for testing predatory behavior and health in the octopus

Piero Amodio, Paul Andrews, Marinella Salemme, Giovanna Ponte, Graziano Fiorito

494-499

Building shared experience to advance practical application of pathway-based toxicology: Liver toxicity mode-of-action

Catherine Willett, Jessica Caverly Rae, Katy O. Goyak, Gary Minsavage, Carl Westmoreland, Melvin Andersen, Mark Avigan, Daniel Duché, Georgina Harris, Thomas Hartung, Hartmut Jaeschke, Andre Kleensang, Brigitte Landesmann, Suzanne Martos, Marilyn Matevia, Colleen Toole, Andrew Rowan, Terry Schultz, Jennifer Seed, John Senior, Imran Shah, Kalyanasundaram Subramanian, Mathieu Vinken, Paul Watkins

500-519

Alternative methods for the use of non-human primates in biomedical research

Saskia M. Burm, Jan-Bas Prins, Jan Langermans, Jeffrey J. Bajramovic

520-529

Addendum to Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

Nina Hasiwa, Mardas Daneshian, Peter Bruegger, Stefan Fennrich, Astrid Hochadel, Sebastian Hoffmann, Felix E. Rivera-Mariani, Christoph Rockel, Stefanie Schindler, Ingo Spreitzer, Sandra Stoppelkamp, Kranthi Vysyaraju, Thomas Hartung

499