Editorial

Sonja von Aulock

U2

The exposome – a new approach for risk assessment

Fenna C. M. Sillé, Spyros Karakitsios, Andre Kleensang, Kirsten Koehler, Alexandra Maertens, Gary W. Miller, Carsten Prasse, Lesliam Quiros-Alcala, Gurumurthy Ramachandran, Stephen M. Rappaport, Ana M. Rule, Denis Sarigiannis, Lena Smirnova, Thomas Hartung

3-23

Machine learning prediction of cyanobacterial toxin (microcystin) toxicodynamics in humans

Stefan Altaner, Sabrina Jaeger, Regina Fotler, Ivan Zemskov, Valentin Wittmann, Falk Schreiber, Daniel R. Dietrich

24-36

Extending the concept of predicting fish acute toxicity in vitro to the intestinal cell line RTgutGC

Hannah Schug, Jenny Maner, Maren Hülskamp, Frédéric Begnaud, Christian Debonneville, Fabienne Berthaud, Sylvia Gimeno, Kristin Schirmer

37-46

3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow – application in systems toxicology

Carine Poussin, Bart Kramer, Henriette L. Lanz, Angelique van den Heuvel, Alexandra Laurent, Thomas Olivier, Marjolein Vermeer, Dariusz Peric, Karine Baumer, Rémi Dulize, Emmanuel Guedj, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng, Jos Joore

47-63

AOPERA: A proposed methodology and inventory of effective tools to link chemicals to adverse outcome pathways

Taylor E. Rycroft, Christy M. Foran, Adam Thrash, Jeffrey C. Cegan, Robert Zollinger, Igor Linkov, Edward J. Perkins, Natàlia Garcia-Reyero

64-74

Multilayered fibroblasts constructed by accelerated cellular self-assembly and applications for regenerative medicine

Paninee Chetprayoon, Sasitorn Aueviriyavit, Arisara Prateep, Sirima Boonjing, Rawiwan Maniratanachote

75-84

Bisphenol A binding promiscuity: A virtual journey through the universe of proteins

Elena Lo Piparo, Lydia Siragusa, Frederic Raymond, Giovanna I. Passeri, Gabriele Cruciani, Benoît Schilter

85-94

A novel approach to increase robustness, precision and high-throughput capacity of single cell gel electrophoresis

Juan C. Cassano, Matthias Roesslein, Rolf Kaufmann, Thomas Luethi, Oliver Schicht, Peter Wick, Cordula Hirsch

95-109

Development of an ex vivo aneurysm model for vascular device testing

Noemi Vanerio, Marco Stijnen, Bas A. J. M. de Mol, Linda M. Kock

110-120

Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment

Anke M. Tukker, Regina G. D. M. van Kleef, Fiona M. J. Wijnolts, Aart de Groot, Remco H. S. Westerink

121-135

iPS, organoids and 3D models as advanced tools for in vitro toxicology

Nathalie Steimberg, Alessia Bertero, Valeria Chiono, Patrizia Dell'Era, Silvia Di Angelantonio, Thomas Hartung, Silvia Perego, Manuela T. Raimondi, Christodoulos Xinaris, Francesca Caloni, Isabella De Angelis, Susanna Alloisio, Diego Baderna

136-140

Corners

Sonja von Aulock

143-154

Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

Alice Krebs, Johanna Nyffeler, Christiaan Karreman, Béla Z. Schmidt, Franziska Kappenberg, Jan Mellert, Giorgia Pallocca, Manuel Pastor, Jörg Rahnenführer, Marcel Leist

155-163

Erratum to Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data

Alice Krebs, Tanja Waldmann, Martin F. Wilks, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Joelle Ruegg, Costanza Rovida, Emma Pedersen, Giorgia Pallocca, Mirjam Luijten, Sofia B. Leite, Stefan Kustermann, Hennicke Kamp, Julia Hoeng, Philip Hewitt, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Florian Gantner, Ellen Fritsche, Kristina Fant, Janine Ezendam, Thomas Exner, Torsten Dunkern, Daniel R. Dietrich, Sandra Coecke, Francois Busquet, Albert Braeuning, Olesja Bondarenko, Susanne H. Bennekou, Mario Beilmann, Marcel Leist

164

Imprint

Sonja von Aulock

U3

Cover

Sonja von Aulock

U1-U4