Evidence-based toxicology for the 21st century: Opportunities and challenges

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Martin L. Stephens
Melvin Andersen
Richard A. Becker
Kellyn Betts
Kim Boekelheide
Ed Carney
Robert Chapin
Dennis Devlin
Suzanne Fitzpatrick
John R. Fowle III
Patricia Harlow
Thomas Hartung
Sebastian Hoffmann
Michael Holsapple
Abigail Jacobs
Richard Judson
Olga Naidenko
Tim Pastoor
Grace Patlewicz
Andrew Rowan
Roberta Scherer
Rashid Shaikh
Ted Simon
Douglas Wolf
Joanne Zurlo


The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on “Evidence-based Toxicology for the 21st Century: Opportunities and Challenges” in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathway-based testing methods consistent with the 2007 National Research Council report on “Toxicity Testing in the 21st Century” as well as to adopt a governance structure and work processes to move that effort forward. The workshop served to clarify evidence-based approaches and to provide food for thought on substantive and administrative activities for the EBTC. Priority activities include conducting pilot studies to demonstrate the value of evidence-based approaches to toxicology, as well as conducting educational outreach on these approaches.

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How to Cite
Stephens, M. L., Andersen, M., Becker, R. A., Betts, K., Boekelheide, K., Carney, E., Chapin, R., Devlin, D., Fitzpatrick, S., Fowle III, J. R., Harlow, P., Hartung, T., Hoffmann, S., Holsapple, M., Jacobs, A., Judson, R., Naidenko, O., Pastoor, T., Patlewicz, G., Rowan, A., Scherer, R., Shaikh, R., Simon, T., Wolf, D. and Zurlo, J. (2013) “Evidence-based toxicology for the 21st century: Opportunities and challenges”, ALTEX - Alternatives to animal experimentation, 30(1), pp. 74–103. doi: 10.14573/altex.2013.1.074.
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