Toxicology ontology perspectives

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Barry Hardy
Gordana Apic
Philip Carthew
Dominic Clark
David Cook
Ian Dix
Sylvia Escher
Janna Hastings
David J. Heard
Nina Jeliazkova
Philip Judson
Sherri Matis-Mitchell
Dragana Mitic
Glenn Myatt
Imran Shah
Ola Spjuth
Olga Tcheremenskaia
Luca Toldo
David Watson
Andrew White
Chihae Yang


The field of predictive toxicology requires the development of open, public, computable, standardized toxicology vocabularies and ontologies to support the applications required by in silico, in vitro, and in vivo toxicology methods and related analysis and reporting activities. In this article we review ontology developments based on a set of perspectives showing how ontologies are being used in predictive toxicology initiatives and applications. Perspectives on resources and initiatives reviewed include OpenTox, eTOX, Pistoia Alliance, ToxWiz, Virtual Liver, EU-ADR, BEL, ToxML, and Bioclipse. We also review existing ontology developments in neighboring fields that can contribute to establishing an ontological framework for predictive toxicology. A significant set of resources is already available to provide a foundation for an ontological framework for 21st century mechanistic-based toxicology research. Ontologies such as ToxWiz provide a basis for application to toxicology investigations, whereas other ontologies under development in the biological, chemical, and biomedical communities could be incorporated in an extended future framework. OpenTox has provided a semantic web framework for the implementation of such ontologies into software applications and linked data resources. Bioclipse developers have shown the benefit of interoperability obtained through ontology by being able to link their workbench application with remote OpenTox web services. Although these developments are promising, an increased international coordination of efforts is greatly needed to develop a more unified, standardized, and open toxicology ontology framework.

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How to Cite
Hardy, B., Apic, G., Carthew, P., Clark, D., Cook, D., Dix, I., Escher, S., Hastings, J., Heard, D. J., Jeliazkova, N., Judson, P., Matis-Mitchell, S., Mitic, D., Myatt, G., Shah, I., Spjuth, O., Tcheremenskaia, O., Toldo, L., Watson, D., White, A. and Yang, C. (2012) “Toxicology ontology perspectives”, ALTEX - Alternatives to animal experimentation, 29(2), pp. 139–156. doi: 10.14573/altex.2012.2.139.

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