Editorial

Sonja von Aulock

U2

Developing context appropriate toxicity testing approaches using new alternative methods (NAMs)

Melvin E. Andersen, Patrick D. McMullen, Martin B. Phillips, Miyoung Yoon, Salil N. Pendse, Harvey J. Clewell, Jessica K. Hartman, Marjory Moreau, Richard A. Becker, Rebecca A. Clewell

523-534

Opportunities for refinement in neuroscience: Indicators of wellness and post-operative pain in laboratory macaques

Kris A. Descovich, Susan E. Richmond, Matthew C. Leach, Hannah M. Buchanan-Smith, Paul Flecknell, David A. H. Farningham, Claire Witham, M. Carolyn Gates, Sarah-Jane Vick

535-554

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition

Jie Mei, Stefanie Banneke, Janet Lips, Melanie T. C. Kuffner, Christian J. Hoffmann, Ulrich Dirnagl, Matthias Endres, Christoph Harms, Julius V. Emmrich

555-571

Assessment of iron oxide nanoparticle ecotoxicity on regeneration and homeostasis in the replacement model system Schmidtea mediterranea

Thao A. Tran, Michelle Hesler, Oscar H. Moriones, Alba Jimeno-Romero, Benjamin Fischer, Neus G. Bastús, Victor Puntes, Sylvia Wagner, Yvonne L. Kohl, Luca Gentile

583-596

Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing

James C. Y. Chan, Shawn P. F. Tan, Zee Upton, Eric C. Y. Chan

597-612

The HaCaT/THP-1 cocultured activation test (COCAT) for skin sensitization: A study of intra-laboratory reproducibility and predictivity

Chantra Eskes, Jennifer Hennen, Mario T. Schellenberger, Sebastian Hoffmann, Sabine Frey, Daniela Goldinger-Oggier, Niklas Peter, Erwin van Vliet, Brunhilde Blömeke

613-622

Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model

Stefania Serra, Monica Vaccari, Maria Grazia Mascolo, Francesca Rotondo, Cristina Zanzi, Laura Polacchini, Christine Behle Wagner, Thorsten Kunkelmann, Sabine Perschbacher, Albrecht Poth, Sandro Grilli, Miriam N. Jacobs, Annamaria Colacci

623-633

Innovative in vitro method to study ventilator induced lung injury

Jon P. Joelsson, Iwona T. Myszor, Ari J. Arason, Saevar Ingthorsson, Paulina Cherek, Gabriel S. Windels, Kristjan Leosson, Gudmundur H. Gudmundsson, Thorarinn Gudjonsson, Sigurbergur Karason

634-642

An intact insect embryo for developmental neurotoxicity testing of directed axonal elongation

Gregor A. Bergmann, Sarah Frömbling, Nina Joseph, Karsten Bode, Gerd Bicker, Michael Stern

643-649

Organ-on-chip in development: Towards a roadmap for organs-on-chip

Massimo Mastrangeli, Sylvie Millet, The ORCHID partners, Janny van den Eijnden-van Raaij

650-668

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Alice Krebs, Tanja Waldmann, Martin F. Wilks, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Joelle Ruegg, Costanza Rovida, Emma Pedersen, Giorgia Pallocca, Mirjam Luijten, Sofia B. Leite, Stefan Kustermann, Hennicke Kamp, Julia Hoeng, Philip Hewitt, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Florian Gantner, Ellen Fritsche, Kristina Fant, Janine Ezendam, Thomas Exner, Torsten Dunkern, Daniel R. Dietrich, Sandra Coecke, Francois Busquet, Albert Braeuning, Olesja Bondarenko, Susanne H. Bennekou, Mario Beilmann, Marcel Leist

682-699