Editorial

Sonja von Aulock

U2

Toward Good In Vitro Reporting Standards

Thomas Hartung, Rob de Vries, Sebastian Hoffmann, Helena T. Hogberg, Lena Smirnova, Katya Tsaioun, Paul Whaley, Marcel Leist

3-17

A three-dimensional model to study human synovial pathology

Mathijs G. A. Broeren, Claire E. J. Waterborg, Renske Wiegertjes, Rogier M. Thurlings, Marije I. Koenders, Peter L. E. M. van Lent, Peter M. van der Kraan, Fons A. J. van de Loo

18-28

An ex vivo porcine spleen perfusion as a model of bacterial sepsis

Wen Y. Chung, Joseph J. Wanford, Rohan Kumar, John D. Isherwood, Richard D. Haigh, Marco R. Oggioni, Ashley R. Dennison, Giuseppe Ercoli

29-38

Investigating cell type specific mechanisms contributing to acute oral toxicity

Pilar Prieto, Rabea Graepel, Kirsten Gerloff, Lara Lamon, Magdalini Sachana, Francesca Pistollato, Laura Gribaldo, Anna Bal-Price, Andrew Worth

39-64

Botulinum toxin testing on animals is still a Europe-wide issue

Katy Taylor, Corina Gericke, Laura Rego Alvarez

81-90

Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways

Edward J. Perkins, Kalyan Gayen, Jason E. Shoemaker, Philipp Antczak, Lyle Burgoon, Francesco Falciani, Steve Gutsell, Geoff Hodges, Aude Kienzler, Dries Knapen, Mary McBride, Catherine Willett, Francis J. Doyle III, Natàlia Garcia-Reyero

91-102

Characterizing sources of variability in zebrafish embryo screening protocols

Jon T. Hamm, Patricia Ceger, David Allen, Matt Stout, Elizabeth A. Maull, Greg Baker, Amy Zmarowski, Stephanie Padilla, Edward Perkins, Antonio Planchart, Donald Stedman, Tamara Tal, Robert L. Tanguay, David C. Volz, Mitch S. Wilbanks, Nigel J. Walker

103-120

Corners

Sonja von Aulock

148-153

Imprint

Sonja von Aulock

U3

Cover

Sonja von Aulock

U1-U4